1 to 10 of 13 literature results

• Purification and unique properties of mammary epithelial stem cells.

  Elucidation of the cellular and molecular mechanisms that maintain mammary epithelial tissue integrity is of broad interest and paramount to the desig…

  Authors: John Stingl, Peter Eirew, Ian Ricketson, Mark Shackleton, François Vaillant, David Choi, Haiyan I Li, Connie J Eaves

  Source: Nature. 2006 Feb 23

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• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

  Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop f…

  Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…

  Source: Nature medicine. 2009 Aug

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• Generation of a functional mammary gland from a single stem cell.

  The existence of mammary stem cells (MaSCs) has been postulated from evidence that the mammary gland can be regenerated by transplantation of epitheli…

  Authors: Mark Shackleton, François Vaillant, Kaylene J Simpson, John Stingl, Gordon K Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J Lindeman, Jane E Visvader

  Source: Nature. 2006 Jan 5

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• The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.

  The cells of origin and mechanisms that underpin tumor heterogeneity in breast cancer are poorly understood. Here, we have examined three mouse models…

  Authors: François Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Natasha C Forrest, Geoffrey J Lindeman, Jane E Visvader

  Source: Cancer research. 2008 Oct 1

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• Steroid hormone receptor status of mouse mammary stem cells.

  The estrogen receptor alpha (ERalpha), progesterone receptor (PR), and erbB2 (Her2 in humans) are important prognostic markers of human breast cancer,…

  Authors: Marie-Liesse Asselin-Labat, Mark Shackleton, John Stingl, François Vaillant, Natasha C Forrest, Connie J Eaves, Jane E Visvader, Geoffrey J Lindeman

  Source: Journal of the National Cancer Institute. 2006 Jul 19

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• Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo.

  Members of the Runx and MYC families have been implicated as collaborating oncogenes. The mechanism of this potent collaboration is elucidated in this…

  Authors: Karen Blyth, François Vaillant, Linda Hanlon, Nancy Mackay, Margaret Bell, Alma Jenkins, James C Neil, Ewan R Cameron

  Source: Cancer research. 2006 Feb 15

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• Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain.

  The Runx2 (Cbfa1, Aml3, PEBP2alphaA) gene plays an essential role in bone development and is one of a three-member family of closely related genes tha…

  Authors: Anne Terry, Anna Kilbey, François Vaillant, Monica Stewart, Alma Jenkins, Ewan Cameron, James C Neil

  Source: Gene. 2004 Jul 7

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• Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

  The recent identification of mouse mammary stem cells (MaSCs) and progenitor subpopulations has enhanced the prospect of investigating the genetic con…

  Authors: Toula Bouras, Bhupinder Pal, François Vaillant, Gwyndolen Harburg, Marie-Liesse Asselin-Labat, Samantha R Oakes, Geoffrey J Lindeman, Jane E Visvader

  Source: Cell stem cell. 2008 Oct 9

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• The emerging picture of the mouse mammary stem cell.

  The isolation and characterisation of mammary stem cells is an important step towards elucidating the hierarchy of epithelial cell development in the …

  Authors: François Vaillant, Marie-Liesse Asselin-Labat, Mark Shackleton, Geoffrey J Lindeman, Jane E Visvader

  Source: Stem cell reviews. 2007 Jun

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• Lineage Enforcement by Inductive Mesenchyme on Adult Epithelial Stem Cells across Developmental Germ Layers.

  During development, cell differentiation is accompanied by the progressive loss of pluripotent gene expression and developmental potential, although d…

  Authors: Renea A Taylor, Hong Wang, Sarah E Wilkinson, Michelle G Richards, Kara Britt, François Vaillant, Geoffrey J Lindeman, Jane E Visvader, Gerald R Cunha, Justin St John,…

  Source: Stem cells (Dayton, Ohio). 2009 Oct 27

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