1 to 10 of 35 literature results

• A human phenome-interactome network of protein complexes implicated in genetic disorders.

  We performed a systematic, large-scale analysis of human protein complexes comprising gene products implicated in many different categories of human d…

  Authors: Kasper Lage, E Olof Karlberg, Zenia M Størling, Páll I Olason, Anders G Pedersen, Olga Rigina, Anders M Hinsby, Zeynep Tümer, Flemming Pociot, Niels Tommerup,…

  Source: Nature biotechnology. 2007 Mar

  View Full Text

• Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.

  OBJECTIVE: Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common gene…

  Authors: Patrick Concannon, Wei-Min Chen, Cécile Julier, Grant Morahan, Beena Akolkar, Henry A Erlich, Joan E Hilner, Jørn Nerup, Concepcion Nierras, Flemming Pociot,…

  Source: Diabetes. 2009 Apr

  View Full Text

• PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.

  The PTPN22 gene, encoding the lymphoid-specific protein tyrosine phosphatase, a negative regulator in the T-cell activation and development, has been …

  Authors: Claude Chelala, Sabine Duchatelet, Marie-Line Joffret, Regine Bergholdt, Danièle Dubois-Laforgue, Pegah Ghandil, Flemming Pociot, Sophie Caillat-Zucman, José Timsit, Cécile Julier

  Source: Diabetes. 2007 Feb

  View Full Text

• Novel analytical methods applied to type 1 diabetes genome-scan data.

  Complex traits like type 1 diabetes mellitus (T1DM) are generally taken to be under the influence of multiple genes interacting with each other to con…

  Authors: Flemming Pociot, Allan E Karlsen, Claus B Pedersen, Mogens Aalund, Jørn Nerup, European Consortium for IDDM Genome Studies

  Source: American journal of human genetics. 2004 Apr

  View Free Full Text

• A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.

  OBJECTIVE: The Type 1 Diabetes Genetics Consortium (T1DGC) has assembled and genotyped a large collection of multiplex families for the purpose of map…

  Authors: Patrick Concannon, Suna Onengut-Gumuscu, John A Todd, Deborah J Smyth, Flemming Pociot, Regine Bergholdt, Beena Akolkar, Henry A Erlich, Joan E Hilner, Cécile Julier,…

  Source: Diabetes. 2008 Oct

  View Full Text

• OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.

  Both genetic and nongenetic factors contribute to the development of type 1 diabetes. Many investigations, including prospective studies of high-risk …

  Authors: L Leigh Field, Vagn Bonnevie-Nielsen, Flemming Pociot, Shao Lu, Thomas B Nielsen, Henning Beck-Nielsen

  Source: Diabetes. 2005 May

  View Full Text

• Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.

  It is likely that human genetic differences mediate susceptibility to viral infection and virus-triggered disorders. OAS genes encoding the antiviral …

  Authors: Vagn Bonnevie-Nielsen, L Leigh Field, Shao Lu, Dong-Jun Zheng, Min Li, Pia M Martensen, Thomas B Nielsen, Henning Beck-Nielsen, Yu-Lung Lau, Flemming Pociot

  Source: American journal of human genetics. 2005 Apr

  View Free Full Text

• Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families.

  Type 1 diabetes is a common, multifactorial disease with strong familial clustering (genetic risk ratio [lambda(S)] approximately 15). Approximately 4…

  Authors: Patrick Concannon, Henry A Erlich, Cecile Julier, Grant Morahan, Jørn Nerup, Flemming Pociot, John A Todd, Stephen S Rich, Type 1 Diabetes Genetics Consortium

  Source: Diabetes. 2005 Oct

  View Full Text

• CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.

  Type 1 diabetes (T1D) is a multifactorial disease with genetic and environmental components involved. Recent studies of an animal model of T1D, the Ko…

  Authors: Regine Bergholdt, Camilla Taxvig, Stefanie Eising, Jørn Nerup, Flemming Pociot

  Source: Journal of leukocyte biology. 2005 Apr

  View Full Text

• Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females.

  The type 1 diabetes mellitus (T1DM) candidate gene SNP IL6-174G/C was genotyped in 253 Danish T1DM families (1129 individuals). TDT analysis demonstra…

  Authors: Ole P Kristiansen, Runa L Nolsøe, Lykke Larsen, Anette M P Gjesing, Jesper Johannesen, Zenia M Larsen, Anne E Lykkesfeldt, Allan E Karlsen, Flemming Pociot, Thomas Mandrup-Poulsen,…

  Source: Human molecular genetics. 2003 May 15

  View Full Text