1 to 9 of 9 literature results

• Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis.

  It remains unclear whether a microRNA (miRNA) affects a given phenotype via concomitant down-regulation of its entire repertoire of targets or instead…

  Authors: Scott Valastyan, Nathan Benaich, Amelia Chang, Ferenc Reinhardt, Robert A Weinberg

  Source: Genes & development. 2009 Nov 15

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• A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis.

  MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially en…

  Authors: Scott Valastyan, Ferenc Reinhardt, Nathan Benaich, Diana Calogrias, Attila M Szász, Zhigang C Wang, Jane E Brock, Andrea L Richardson, Robert A Weinberg

  Source: Cell. 2009 Jun 12

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• miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.

  MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in bre…

  Authors: Li Ma, Jennifer Young, Harsha Prabhala, Elizabeth Pan, Pieter Mestdagh, Daniel Muth, Julie Teruya-Feldstein, Ferenc Reinhardt, Tamer T Onder, Scott Valastyan,…

  Source: Nature cell biology. 2010 Mar

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• Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.

  The p53 tumor suppressor is a key mediator of cellular responses to various stresses. Here, we show that under conditions of basal physiologic and cel…

  Authors: Samuel Godar, Tan A Ince, George W Bell, David Feldser, Joana Liu Donaher, Jonas Bergh, Anne Liu, Kevin Miu, Randolph S Watnick, Ferenc Reinhardt,…

  Source: Cell. 2008 Jul 11

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• Systemic endocrine instigation of indolent tumor growth requires osteopontin.

  The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we…

  Authors: Sandra S McAllister, Ann M Gifford, Ashley L Greiner, Stephen P Kelleher, Matthew P Saelzler, Tan A Ince, Ferenc Reinhardt, Lyndsay N Harris, Bonnie L Hylander, Elizabeth A Repasky,…

  Source: Cell. 2008 Jun 13

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• Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

  RATIONALE: Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the…

  Authors: Prakash K Rao, Yumiko Toyama, H Rosaria Chiang, Sumeet Gupta, Michael Bauer, Rostislav Medvid, Ferenc Reinhardt, Ronglih Liao, Monty Krieger, Rudolf Jaenisch,…

  Source: Circulation research. 2009 Sep 11

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• Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.

  The identification of mammary gland stem cells (MGSC) or progenitors is important for the study of normal breast development and tumorigenesis. Based …

  Authors: Mai-Jing Liao, Cheng Cheng Zhang, Beiyan Zhou, Drazen B Zimonjic, Sendurai A Mani, Megan Kaba, Ann Gifford, Ferenc Reinhardt, Nicholas C Popescu, Wenjun Guo,…

  Source: Cancer research. 2007 Sep 1

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• IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.

  The mechanisms by which prolactin controls proliferation of mammary epithelial cells (MECs) and morphogenesis of the breast epithelium are poorly unde…

  Authors: Cathrin Brisken, Ayyakkannu Ayyannan, Cuc Nguyen, Anna Heineman, Ferenc Reinhardt, Jian Tan, S K Dey, G Paolo Dotto, Robert A Weinberg, Tian Jan

  Source: Developmental cell. 2002 Dec

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• The Spemann organizer gene, Goosecoid, promotes tumor metastasis.

  The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. …

  Authors: Kimberly A Hartwell, Beth Muir, Ferenc Reinhardt, Anne E Carpenter, Dennis C Sgroi, Robert A Weinberg

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Dec 12

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