1 to 4 of 4 literature results

• A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

  Chromatin modification is considered to be a fundamental mechanism of regulating gene expression to generate coordinated responses to environmental ch…

  Authors: Jiuhong Kang, Yufeng Shi, Bin Xiang, Bin Qu, Wenjuan Su, Min Zhu, Min Zhang, Guobin Bao, Feifei Wang, Xiaoqing Zhang,…

  Source: Cell. 2005 Dec 2

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• Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus.

  Upon ligand binding, G-protein-coupled receptors (GPCRs) impart the signal to heterotrimeric G proteins composed of alpha, beta, and gamma subunits, l…

  Authors: Yuhui Jiang, Xiaoduo Xie, Yixuan Zhang, Xiaolin Luo, Xiao Wang, Fengjuan Fan, Dawei Zheng, Zhenzhen Wang, Yan Chen

  Source: Molecular and cellular biology. 2010 Jan

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• RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.

  Raf kinase trapping to Golgi (RKTG) is a newly characterized negative regulator of the Ras-Raf-mitogen-activated and extracellular signal-regulated ki…

  Authors: Fengjuan Fan, Lin Feng, Jing He, Xiao Wang, Xiaomeng Jiang, Yixuan Zhang, Zhenzhen Wang, Yan Chen

  Source: Carcinogenesis. 2008 Jun

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• Spatial regulation of Raf kinase signaling by RKTG.

  Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK by Sef. Here…

  Authors: Lin Feng, Xiaoduo Xie, Qiurong Ding, Xiaolin Luo, Jing He, Fengjuan Fan, Weizhong Liu, Zhenzhen Wang, Yan Chen

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Sep 4

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