1 to 9 of 9 literature results

• The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.

  The p75(NTR) acts as a tumor suppressor in the prostate, but its expression is lost as prostate cancer progresses and is minimal in established prosta…

  Authors: Emily J Quann, Fatima Khwaja, Daniel Djakiew

  Source: Cancer research. 2007 Dec 1

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• The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.

  Epidemiologic studies show that patients chronically consuming nonsteroidal anti-inflammatory drugs (NSAID) for arthritis exhibit a reduced incidence …

  Authors: Emily J Quann, Fatima Khwaja, Kenton H Zavitz, Daniel Djakiew

  Source: Cancer research. 2007 Apr 1

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• Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein.

  Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to reduce inflammation and as analgesics by inhibition of cyclooxygenase-2. At higher concentra…

  Authors: Fatima Khwaja, Jeff Allen, John Lynch, Peter Andrews, Daniel Djakiew

  Source: Cancer research. 2004 Sep 1

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• The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells.

  The p75 neurotrophin receptor (p75(NTR)) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. Th…

  Authors: Fatima Khwaja, Arshia Tabassum, Jeff Allen, Daniel Djakiew

  Source: Biochemical and biophysical research communications. 2006 Mar 24

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• Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.

  Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target…

  Authors: Chalet Tan, Rita G de Noronha, Anthony J Roecker, Beata Pyrzynska, Fatima Khwaja, Zhaobin Zhang, Huanchun Zhang, Quincy Teng, Ainsley C Nicholson, Paraskevi Giannakakou,…

  Source: Cancer research. 2005 Jan 15

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• The p75NTR mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival.

  p75NTR is most abundantly expressed in the nervous system, but is also widely expressed in many other organs and tissues where it primarily functions …

  Authors: Jeffrey Allen, Fatima Khwaja, Stephen Byers, Daniel Djakiew

  Source: Experimental cell research. 2005 Mar 10

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• Inhibition of cell-cycle effectors of proliferation in bladder tumor epithelial cells by the p75NTR tumor suppressor.

  The neurotrophin (NTR) receptor (p75(NTR)) is a cell-surface glycoprotein that binds to the neurotrophin family of growth factors, of which the protot…

  Authors: Fatima Khwaja, Daniel Djakiew

  Source: Molecular carcinogenesis. 2003 Mar

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• Gene therapy of prostate xenograft tumors with a p75NTR lipoplex.

  The p75neurotrophin receptor (p75NTR) has been characterized as a tumor suppressor in human prostate cancer. Ectopic re-expression of this cell surfac…

  Authors: Jeffrey Allen, Fatima Khwaja, Daniel Djakiew

  Source: Anticancer research. 2004 Sep-Oct

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• The p75(NTR) tumor suppressor induces caspase-mediated apoptosis in bladder tumor cells.

  p75(NTR) was identified as a tumor and metastasis suppressor that functions in part via induction of apoptosis in tumor cells. To examine p75(NTR)-dep…

  Authors: Arshia Tabassum, Fatima Khwaja, Daniel Djakiew

  Source: International journal of cancer. Journal international du cancer. 2003 May 20

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