1 to 10 of 1,056 literature results

• Smad3 phosphorylation by cyclin-dependent kinases.

  Smad3, a key mediator for TGF-beta antiproliferative responses, is phosphorylated by both CDK4 and CDK2 in vivo and in vitro. Except for the Rb family…

  Authors: Fang Liu

  Source: Cytokine & growth factor reviews. 2006 Feb-Apr

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• Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.

  We conducted a genome-wide association study of generalized vitiligo in the Chinese Han population by genotyping 1,117 cases and 1,429 controls. The 3…

  Authors: Cheng Quan, Yun-Qing Ren, Lei-Hong Xiang, Liang-Dan Sun, Ai-E Xu, Xing-Hua Gao, Hong-Duo Chen, Xiong-Ming Pu, Ri-Na Wu, Chao-Zhao Liang,…

  Source: Nature genetics. 2010 Jul

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• Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice.

  Although the role of systemic activation of the nuclear factor kappaB (NF-kappaB) pathway in septic coagulation has been well documented, little is kn…

  Authors: Dongmei Song, Xiaobing Ye, Honglei Xu, Shu Fang Liu

  Source: Blood. 2009 Sep 17

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• Cyclin-dependent kinases regulate the antiproliferative function of Smads.

  Transforming growth factor-beta (TGF-beta) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in mediating the TGF-bet…

  Authors: Isao Matsuura, Natalia G Denissova, Guannan Wang, Dongming He, Jianyin Long, Fang Liu

  Source: Nature. 2004 Jul 8

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• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory.

  The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpre…

  Authors: Bechara J Saab, John Georgiou, Arup Nath, Frank J S Lee, Min Wang, Aubin Michalon, Fang Liu, Isabelle M Mansuy, John C Roder

  Source: Neuron. 2009 Sep 10

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• Genetic factors involved in the pathogenesis of Parkinson's disease.

  Parkinson's disease (PD) is a neurodegenerative disease characterized by a loss of nigrostriatal dopaminergic neurons. Recently, PD research has been …

  Authors: Frank J S Lee, Fang Liu

  Source: Brain research reviews. 2008 Aug

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• ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia.

  ADAR2 is a nuclear enzyme essential for GluR2 pre-mRNA editing at Q/R site-607, which gates Ca2+ entry through AMPA receptor channels. Here, we show t…

  Authors: Peter L Peng, Xiafen Zhong, Weihong Tu, Mangala M Soundarapandian, Peter Molner, Dongya Zhu, Lorraine Lau, Shuhong Liu, Fang Liu, Youming Lu

  Source: Neuron. 2006 Mar 2

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• KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.

  Signaling through the transforming growth factor-beta (TGF-beta) pathway results in growth inhibition and induction of apoptosis in various cell types…

  Authors: Daniel L Di Bartolo, Mark Cannon, Yi-Fang Liu, Rolf Renne, Amy Chadburn, Chris Boshoff, Ethel Cesarman

  Source: Blood. 2008 May 1

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• FMRP acts as a key messenger for dopamine modulation in the forebrain.

  The fragile X mental retardation protein (FMRP) is an RNA-binding protein that controls translational efficiency and regulates synaptic plasticity. He…

  Authors: Hansen Wang, Long-Jun Wu, Susan S Kim, Frank J S Lee, Bo Gong, Hiroki Toyoda, Ming Ren, Yu-Ze Shang, Hui Xu, Fang Liu,…

  Source: Neuron. 2008 Aug 28

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• Heme iron nitrosyl complex of MauG reveals an efficient redox equilibrium between hemes with only one heme exclusively binding exogenous ligands.

  MauG is a diheme enzyme that oxidizes two protein-bound tryptophan residues to generate a catalytic tryptophan tryptophylquinone cofactor within methy…

  Authors: Rong Fu, Fange Liu, Victor L Davidson, Aimin Liu

  Source: Biochemistry. 2009 Dec 15

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