1 to 10 of 127 literature results

• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs,…

  Authors: F Penna, P Reffo, G Muzio, R A Canuto, F M Baccino, G Bonelli, P Costelli

  Source: Biochemical pharmacology. 2009 Jan 15

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• Muscle myostatin signalling is enhanced in experimental cancer cachexia.

  BACKGROUND/AIMS: Myostatin belongs to the transforming growth factor-beta superfamily and negatively regulates skeletal muscle mass. Its deletion indu…

  Authors: P Costelli, M Muscaritoli, A Bonetto, F Penna, P Reffo, M Bossola, G Bonelli, G B Doglietto, F M Baccino, F Rossi Fanelli

  Source: European journal of clinical investigation. 2008 Jul

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• Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody.

  The liver is particularly susceptible to Fas-mediated cytotoxicity. Mice given an adequate parenteral dose of agonistic anti-Fas antibody (aFas) or of…

  Authors: P Costelli, P Aoki, B Zingaro, N Carbó, P Reffo, F J Lopez-Soriano, G Bonelli, J M Argilés, F M Baccino

  Source: Cell death and differentiation. 2003 Sep

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• Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia.

  Cachexia is a syndrome characterized by profound tissue wasting that frequently complicates malignancies. In a cancer cachexia model we have shown tha…

  Authors: P Costelli, R D Tullio, F M Baccino, E Melloni

  Source: British journal of cancer. 2001 Apr 6

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• Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation.

  Cachexia is a syndrome characterized by profound skeletal muscle wasting that frequently complicates malignancies. A number of studies indicate that p…

  Authors: P Costelli, M Muscaritoli, M Bossola, R Moore-Carrasco, S Crepaldi, G Grieco, R Autelli, G Bonelli, F Pacelli, F J Lopez-Soriano,…

  Source: International journal of oncology. 2005 Jun

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• Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.

  Muscle wasting, as occurring in cancer cachexia, is primarily characterized by protein hypercatabolism and increased expression of ubiquitin ligases, …

  Authors: A Bonetto, F Penna, V G Minero, P Reffo, G Bonelli, F M Baccino, P Costelli

  Source: Current cancer drug targets. 2009 Aug

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• Cancer cachexia: from experimental models to patient management.

  Cachexia is frequently associated with advanced or terminal cancer states, but it can also develop early during the course of neoplastic disease. This…

  Authors: P Costelli, F M Baccino

  Source: Current opinion in clinical nutrition and metabolic care. 2000 May

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• Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats.

  The ascites hepatoma Yoshida AH-130 induces loss of body weight and tissue waste. Tumour necrosis factor alpha (TNF-alpha) plays a pivotal role in the…

  Authors: P Costelli, M Bossola, M Muscaritoli, G Grieco, G Bonelli, R Bellantone, G B Doglietto, F M Baccino, F Rossi Fanelli

  Source: Cytokine. 2002 Jul 7

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• Impaired macrophage phagocytosis of apoptotic neutrophils in patients with human immunodeficiency virus type 1 infection.

  Dysfunction of neutrophils (polymorphonuclear leukocytes [PMNL]) and macrophagic cells occurs as a consequence of human immunodeficiency virus type 1 …

  Authors: Donato Torre, Luisa Gennero, F M Baccino, Filippo Speranza, Gilberto Biondi, Agostino Pugliese

  Source: Clinical and diagnostic laboratory immunology. 2002 Sep

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• Interleukin-15 antagonizes muscle protein waste in tumour-bearing rats.

  Tissue protein hypercatabolism (TPH) is an important feature in cancer cachexia, particularly with regard to the skeletal muscle. The Yoshida AH-130 r…

  Authors: N Carbó, J López-Soriano, P Costelli, S Busquets, B Alvarez, F M Baccino, L S Quinn, F J López-Soriano, J M Argilés

  Source: British journal of cancer. 2000 Aug

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