1 to 9 of 9 literature results

• Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells.

  The reorientation of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell enables the directional secretion of cytokines…

  Authors: Emily J Quann, Ernesto Merino, Toshiaki Furuta, Morgan Huse

  Source: Nature immunology. 2009 Jun

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• Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

  Authors: Isabel Mérida, Antonia Avila-Flores, Job García, Ernesto Merino, María Almena, Pedro Torres-Ayuso

  Source: Advances in enzyme regulation. 2009

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• Diacylglycerol kinases: at the hub of cell signalling.

  DGKs (diacylglycerol kinases) are members of a unique and conserved family of intracellular lipid kinases that phosphorylate DAG (diacylglycerol), cat…

  Authors: Isabel Mérida, Antonia Avila-Flores, Ernesto Merino

  Source: The Biochemical journal. 2008 Jan 1

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• Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells.

  Diacylglycerol kinase (DGK) phosphorylates diacylglycerol to phosphatidic acid, modifying the cellular levels of these two lipid mediators. Ten DGK is…

  Authors: Ernesto Merino, Miguel A Sanjuán, Ignacio Moraga, Angel Ciprés, Isabel Mérida

  Source: The Journal of biological chemistry. 2007 Nov 30

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• Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells.

  TCR engagement triggers phospholipase Cgamma1 activation through the Lck-ZAP70-linker of activated T cell adaptor protein pathway. This leads to gener…

  Authors: Ernesto Merino, Antonia Avila-Flores, Yasuhito Shirai, Ignacio Moraga, Naoaki Saito, Isabel Mérida

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 May 1

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• Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement.

  Directional cell movement in response to external chemical gradients requires establishment of front-rear asymmetry, which distinguishes an up-gradien…

  Authors: Rosa Ana Lacalle, Rosa M Peregil, Juan Pablo Albar, Ernesto Merino, Carlos Martínez-A, Isabel Mérida, Santos Mañes

  Source: The Journal of cell biology. 2007 Dec 31

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• Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol.

  Diacylglycerol kinase (DGK) has been suggested to be a pharmacological target of D-alpha-tocopherol for diabetic renal dysfunctions. However, the DGK …

  Authors: Rika Fukunaga-Takenaka, Yasuhito Shirai, Keiko Yagi, Naoko Adachi, Norio Sakai, Ernesto Merino, Isabel Merida, Naoaki Saito

  Source: Genes to cells : devoted to molecular & cellular mechanisms. 2005 Apr

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• Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes.

  Fas ligand (FasL) mediates both apoptotic and inflammatory responses in the immune system. FasL function critically depends on the different forms of …

  Authors: Roberto Alonso, M Carmen Rodríguez, Jose Pindado, Ernesto Merino, Isabel Mérida, Manuel Izquierdo

  Source: The Journal of biological chemistry. 2005 Aug 5

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• Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products.

  Diacylglycerol kinase alpha (DAGK alpha), like all type I DAGKs, has calcium regulatory motifs that act as negative regulators of enzyme activity and …

  Authors: Angel Ciprés, Silvia Carrasco, Ernesto Merino, Ernesto Díaz, U Murali Krishna, John R Falck, Carlos Martínez-A, Isabel Mérida

  Source: The Journal of biological chemistry. 2003 Sep 12

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