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In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy.
Immunostimulatory cytidyl guanosyl (CpG) motifs are of great interest as cancer vaccine adjuvants. They act as potent inducers of Th1 responses, inclu…
Authors: Stefan Nierkens, Martijn H den Brok, Roger P M Sutmuller, Oliver M Grauer, Erik Bennink, Mary E Morgan, Carl G Figdor, Theo J M Ruers, Gosse J Adema
Source: Cancer research. 2008 Jul 1
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TLR ligands in the local treatment of established intracerebral murine gliomas.
Local TLR stimulation is an attractive approach to induce antitumor immunity. In this study, we compared various TLR ligands for their ability to affe…
Authors: Oliver M Grauer, Johan W Molling, Erik Bennink, Liza W J Toonen, Roger P M Sutmuller, Stefan Nierkens, Gosse J Adema
Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Nov 15
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Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model.
Both melanoma and glioma cells are of neuroectodermal origin and share common tumor associated antigens. In this article, we report that the melanocyt…
Authors: Oliver M Grauer, Roger P M Sutmuller, Wendy van Maren, Joannes F M Jacobs, Erik Bennink, Liza W J Toonen, Stefan Nierkens, Gosse J Adema
Source: International journal of cancer. Journal international du cancer. 2008 Apr 15
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CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo.
The suppressive activity of regulatory T cells (Treg) has been implicated as an important factor limiting immune mediated destruction of tumor cells. …
Authors: Oliver M Grauer, Stefan Nierkens, Erik Bennink, Liza W J Toonen, Louis Boon, Pieter Wesseling, Roger P M Sutmuller, Gosse J Adema
Source: International journal of cancer. Journal international du cancer. 2007 Jul 1
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