1 to 9 of 9 literature results

• Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

  Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determi…

  Authors: Sharon Y Gidekel Friedlander, Gerald C Chu, Eric L Snyder, Nomeda Girnius, Gregory Dibelius, Denise Crowley, Eliza Vasile, Ronald A DePinho, Tyler Jacks

  Source: Cancer cell. 2009 Nov 6

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• Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides.

  Protein transduction domains (PTDs), such as the TAT PTD, have been shown to deliver a wide variety of cargo in cell culture and to treat preclinical …

  Authors: Eric L Snyder, Cheryl C Saenz, Catherine Denicourt, Bryan R Meade, Xian-Shu Cui, Ian M Kaplan, Steven F Dowdy

  Source: Cancer research. 2005 Dec 1

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• Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies.

  Breast carcinoma cells with the CD44+/CD24(low) phenotype have been reported to exhibit 'cancer stem cell' (CSC) characteristics on the basis of their…

  Authors: Eric L Snyder, Dyane Bailey, Michail Shipitsin, Kornelia Polyak, Massimo Loda

  Source: Laboratory investigation; a journal of technical methods and pathology. 2009 Aug

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• Recent advances in the use of protein transduction domains for the delivery of peptides, proteins and nucleic acids in vivo.

  Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian …

  Authors: Eric L Snyder, Steven F Dowdy

  Source: Expert opinion on drug delivery. 2005 Jan

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• c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme.

  Genomic amplification of c-Jun and its upstream kinases have been implicated as a mechanism of progression from well-differentiated to dedifferentiate…

  Authors: Eric L Snyder, Deborah J Sandstrom, Kenneth Law, Christopher Fiore, Ewa Sicinska, Joseph Brito, Dyane Bailey, Jonathan A Fletcher, Massimo Loda, Scott J Rodig,…

  Source: The Journal of pathology. 2009 Jul

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• Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide.

  Advanced-stage peritoneal carcinomatosis is resistant to current chemotherapy treatment and, in the case of metastatic ovarian cancer, results in a de…

  Authors: Eric L Snyder, Bryan R Meade, Cheryl C Saenz, Steven F Dowdy

  Source: PLoS biology. 2004 Feb

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• Anti-cancer protein transduction strategies: reconstitution of p27 tumor suppressor function.

  Significant scientific effort focused on understanding the molecular basis of oncogenesis has identified multiple tumor suppressor genes and their cor…

  Authors: Eric L Snyder, Bryan R Meade, Steven F Dowdy

  Source: Journal of controlled release : official journal of the Controlled Release Society. 2003 Aug 28

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• Cell type-specific DNA methylation patterns in the human breast.

  Cellular identity and differentiation are determined by epigenetic programs. The characteristics of these programs in normal human mammary epithelium …

  Authors: Noga Bloushtain-Qimron, Jun Yao, Eric L Snyder, Michail Shipitsin, Lauren L Campbell, Sendurai A Mani, Min Hu, Haiyan Chen, Vadim Ustyansky, Jessica E Antosiewicz,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep 16

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• Distinct and nonoverlapping roles for pRB and cyclin D:cyclin-dependent kinases 4/6 activity in melanocyte survival.

  Deregulation of the p16INK4a-cyclin D:cyclin-dependent kinases (cdk) 4/6-retinoblastoma (pRB) pathway is a common paradigm in the oncogenic transforma…

  Authors: Benjamin D Yu, Michelle Becker-Hapak, Eric L Snyder, Marc Vooijs, Catherine Denicourt, Steven F Dowdy

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2003 Dec 9

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