Click on one of these terms to refine your search
1 to 10 of 28 literature results
DNA topoisomerases are a class of enzymes that alter the topology of DNA and are targets of several anticancer drugs. Camptothecins (CPTs) are a relat…
Authors: Zeshaan A Rasheed, Eric H Rubin
Source: Oncogene. 2003 Oct 20
View Full TextIFN-stimulatory gene factor 15 (ISG15) is a ubiquitin-like protein, which is conjugated to many cellular proteins. However, its role in protein degrad…
Authors: Shyamal D Desai, Arthur L Haas, Laurence M Wood, Yu-Chen Tsai, Sidney Pestka, Eric H Rubin, Ahamed Saleem, Alam Nur-E-Kamal, Leroy F Liu
Source: Cancer research. 2006 Jan 15
View Full TextTOPORS is the first example of a protein with both ubiquitin and SUMO-1 E3 ligase activity and has been implicated as a tumor suppressor in several di…
Authors: Pooja Pungaliya, Diptee Kulkarni, Hye-Jin Park, Henderson Marshall, Haiyan Zheng, Henry Lackland, Ahamed Saleem, Eric H Rubin
Source: Journal of proteome research. 2007 Oct
View Full TextTOPORS is the first example of a protein that possesses both ubiquitin and SUMO E3 ligase activity. The ubiquitination activity maps to a conserved RI…
Authors: Hye-Jin Park, Haiyan Zheng, Diptee Kulkarni, John Kerrigan, Pooja Pungaliya, Ahamed Saleem, Eric H Rubin
Source: Biochemistry. 2008 Dec 30
View Full TextClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but may involve increased expre…
Authors: Murugesan K Gounder, Ahamed S Nazar, Ahamed Saleem, Pooja Pungaliya, Diptee Kulkarni, Richard Versace, Eric H Rubin
Source: Investigational new drugs. 2008 Jun
View Full TextTopors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes …
Authors: Ahamed Saleem, Jayeeta Dutta, Diptee Malegaonkar, Farheena Rasheed, Zeshaan Rasheed, Rajeev Rajendra, Henderson Marshall, Minje Luo, Honghua Li, Eric H Rubin
Source: Oncogene. 2004 Jul 8
View Full TextBreast cancer resistance protein (BCRP)/MXR/ABCG2 is a new member of the family of ATP-dependent drug efflux proteins. Whereas overexpression of anoth…
Authors: Rajeev Rajendra, Murugesan K Gounder, Ahamed Saleem, Jan H M Schellens, Douglas D Ross, Susan E Bates, Patrick Sinko, Eric H Rubin
Source: Cancer research. 2003 Jun 15
View Full TextTopoisomerase I (Top I)-DNA covalent complexes represent a unique type of DNA lesion whose repair and processing remain unclear. In this study, we sho…
Authors: Shyamal D Desai, Hui Zhang, Alexandra Rodriguez-Bauman, Jin-Ming Yang, Xiaohua Wu, Murugesan K Gounder, Eric H Rubin, Leroy F Liu
Source: Molecular and cellular biology. 2003 Apr
View Free Full TextResistance to topoisomerase I (TOP1)-targeting drugs such as topotecan often involves upregulation of topoisomerase II (TOP2), with accompanying incre…
Authors: Biren Saraiya, Murugesan Gounder, Jayeeta Dutta, Ahamed Saleem, Celeste Collazo, Luz Zimmerman, Ahamed Nazar, Mecide Gharibo, Dale Schaar, Yong Lin,…
Source: Anti-cancer drugs. 2008 Apr
View Full TextWe previously identified topors as a topoisomerase I-binding protein that localizes in punctate nuclear regions when expressed as a GFP fusion protein…
Authors: Zeshaan A Rasheed, Ahamed Saleem, Yaniv Ravee, Pier Paolo Pandolfi, Eric H Rubin
Source: Experimental cell research. 2002 Jul 15
View Full Text