1 to 10 of 28 literature results

• Mechanisms of resistance to topoisomerase I-targeting drugs.

  DNA topoisomerases are a class of enzymes that alter the topology of DNA and are targets of several anticancer drugs. Camptothecins (CPTs) are a relat…

  Authors: Zeshaan A Rasheed, Eric H Rubin

  Source: Oncogene. 2003 Oct 20

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• Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

  IFN-stimulatory gene factor 15 (ISG15) is a ubiquitin-like protein, which is conjugated to many cellular proteins. However, its role in protein degrad…

  Authors: Shyamal D Desai, Arthur L Haas, Laurence M Wood, Yu-Chen Tsai, Sidney Pestka, Eric H Rubin, Ahamed Saleem, Alam Nur-E-Kamal, Leroy F Liu

  Source: Cancer research. 2006 Jan 15

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• TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

  TOPORS is the first example of a protein with both ubiquitin and SUMO-1 E3 ligase activity and has been implicated as a tumor suppressor in several di…

  Authors: Pooja Pungaliya, Diptee Kulkarni, Hye-Jin Park, Henderson Marshall, Haiyan Zheng, Henry Lackland, Ahamed Saleem, Eric H Rubin

  Source: Journal of proteome research. 2007 Oct

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• Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.

  TOPORS is the first example of a protein that possesses both ubiquitin and SUMO E3 ligase activity. The ubiquitination activity maps to a conserved RI…

  Authors: Hye-Jin Park, Haiyan Zheng, Diptee Kulkarni, John Kerrigan, Pooja Pungaliya, Ahamed Saleem, Eric H Rubin

  Source: Biochemistry. 2008 Dec 30

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• Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan.

  Clinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but may involve increased expre…

  Authors: Murugesan K Gounder, Ahamed S Nazar, Ahamed Saleem, Pooja Pungaliya, Diptee Kulkarni, Richard Versace, Eric H Rubin

  Source: Investigational new drugs. 2008 Jun

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• The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.

  Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes …

  Authors: Ahamed Saleem, Jayeeta Dutta, Diptee Malegaonkar, Farheena Rasheed, Zeshaan Rasheed, Rajeev Rajendra, Henderson Marshall, Minje Luo, Honghua Li, Eric H Rubin

  Source: Oncogene. 2004 Jul 8

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• Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.

  Breast cancer resistance protein (BCRP)/MXR/ABCG2 is a new member of the family of ATP-dependent drug efflux proteins. Whereas overexpression of anoth…

  Authors: Rajeev Rajendra, Murugesan K Gounder, Ahamed Saleem, Jan H M Schellens, Douglas D Ross, Susan E Bates, Patrick Sinko, Eric H Rubin

  Source: Cancer research. 2003 Jun 15

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• Transcription-dependent degradation of topoisomerase I-DNA covalent complexes.

  Topoisomerase I (Top I)-DNA covalent complexes represent a unique type of DNA lesion whose repair and processing remain unclear. In this study, we sho…

  Authors: Shyamal D Desai, Hui Zhang, Alexandra Rodriguez-Bauman, Jin-Ming Yang, Xiaohua Wu, Murugesan K Gounder, Eric H Rubin, Leroy F Liu

  Source: Molecular and cellular biology. 2003 Apr

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• Sequential topoisomerase targeting and analysis of mechanisms of resistance to topotecan in patients with acute myelogenous leukemia.

  Resistance to topoisomerase I (TOP1)-targeting drugs such as topotecan often involves upregulation of topoisomerase II (TOP2), with accompanying incre…

  Authors: Biren Saraiya, Murugesan Gounder, Jayeeta Dutta, Ahamed Saleem, Celeste Collazo, Luz Zimmerman, Ahamed Nazar, Mecide Gharibo, Dale Schaar, Yong Lin,…

  Source: Anti-cancer drugs. 2008 Apr

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• The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies.

  We previously identified topors as a topoisomerase I-binding protein that localizes in punctate nuclear regions when expressed as a GFP fusion protein…

  Authors: Zeshaan A Rasheed, Ahamed Saleem, Yaniv Ravee, Pier Paolo Pandolfi, Eric H Rubin

  Source: Experimental cell research. 2002 Jul 15

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