10 literature results

• Application of toxicogenomics to genetic toxicology risk assessment.

  Based on the assumption that compounds having similar toxic modes of action induce specific gene expression changes, the toxicity of unknown compounds…

  Authors: Véronique Thybaud, Anne-Céline Le Fevre, Eric Boitier

  Source: Environmental and molecular mutagenesis. 2007 Jun

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• Proteomic characterization of the effects of clofibrate on protein expression in rat liver.

  Clofibrate is a peroxisome proliferator known to induce liver tumours in rats. A proteomics study was conducted to provide new insights into the molec…

  Authors: Jean-François Léonard, Martine Courcol, Claire Mariet, Aurore Charbonnier, Eric Boitier, Marc Duchesne, Fabienne Parker, Bruno Genet, Françoise Supatto, Ruth Roberts,…

  Source: Proteomics. 2006 Mar

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• Characterization of an acute molecular marker of nongenotoxic rodent hepatocarcinogenesis by gene expression profiling in a long term clofibric acid study.

  Evaluation of the nongenotoxic potential early during the development of a drug presents a major challenge. Recently, two genes were identified as pot…

  Authors: Cécile Michel, Ruth A Roberts, Chantal Desdouets, Kevin R Isaacs, Eric Boitier

  Source: Chemical research in toxicology. 2005 Apr

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• Regulation of apoptosis by peroxisome proliferators.

  Peroxisome proliferators (PPs) constitute a large and chemically diverse family of non-genotoxic rodent hepatocarcinogens that activate the PP-activat…

  Authors: Ruth A Roberts, Cecile Michel, Beth Coyle, Caroline Freathy, Kelvin Cain, Eric Boitier

  Source: Toxicology letters. 2004 Apr 1

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• Laboratory variability does not preclude identification of biological functions impacted by hydroxyurea.

  The multi-lab International Life Sciences Institute (ILSI) project on the application of genomics to risk assessment offered the unique opportunity to…

  Authors: Arne Müller, Eric Boitier, Ting Hu, Gregory J Carr, Anne-Céline Le Fèvre, Jean-Pierre Marchandeau, Manoli Flor, Felicia Jefferson, Marilyn J Aardema, Véronique Thybaud

  Source: Environmental and molecular mutagenesis. 2005 Dec

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• Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.

  Clofibric acid (CLO) is a nongenotoxic hepatocarcinogen in rodents that causes altered hepatocellular foci and/or neoplasms. Initiation by DNA-damagin…

  Authors: Cecile Michel, Chantal Desdouets, Mohamed Slaoui, Kevin Robert Isaacs, Ruth Angela Roberts, Eric Boitier

  Source: Toxicological sciences : an official journal of the Society of Toxicology. 2007 Sep

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• Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling.

  Gene expression profiling technology is expected to advance our understanding of genotoxic mechanisms involving direct or indirect interaction with DN…

  Authors: Anne-Celine Le Fevre, Eric Boitier, Jean-Pierre Marchandeau, Alain Sarasin, Veronique Thybaud

  Source: Mutation research. 2007 Jun 1

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• Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms.

  The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens. However, it features a low specificity and provides only l…

  Authors: Heidrun Ellinger-Ziegelbauer, Jennifer M Fostel, Chinami Aruga, Daniel Bauer, Eric Boitier, Shibing Deng, Donna Dickinson, Anne-Celine Le Fevre, Albert J Fornace, Olivier Grenet,…

  Source: Toxicological sciences : an official journal of the Society of Toxicology. 2009 Aug

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• Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease.

  Peroxisome proliferator activated receptors (PPARs) are a family of related receptors implicated in a diverse array of biological processes. There are…

  Authors: Eric Boitier, Jean-Charles Gautier, Ruth Roberts

  Source: Comparative hepatology. 2003 Jan 31

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• Liver gene expression profiles of rats treated with clofibric acid: comparison of whole liver and laser capture microdissected liver.

  Clofibric acid (CLO) is a peroxisome proliferator (PP) that acts through the peroxisome proliferator activated receptor alpha, leading to hepatocarcin…

  Authors: Cécile Michel, Chantal Desdouets, Béatrice Sacre-Salem, Jean-Charles Gautier, Ruth Roberts, Eric Boitier

  Source: The American journal of pathology. 2003 Dec

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