1 to 5 of 5 literature results

• Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

  Despite the well-documented association between gallstones and the metabolic syndrome, the mechanistic links between these two disorders remain unknow…

  Authors: Sudha B Biddinger, Joel T Haas, Bian B Yu, Olivier Bezy, Enxuan Jing, Wenwei Zhang, Terry G Unterman, Martin C Carey, C Ronald Kahn

  Source: Nature medicine. 2008 Jul

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• SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

  Sirtuins are NAD(+)-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabo…

  Authors: Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,…

  Source: Nature. 2010 Mar 4

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• Deletion of the Nhlh2 transcription factor decreases the levels of the anorexigenic peptides alpha melanocyte-stimulating hormone and thyrotropin-releasing hormone and implicates prohormone convertases I and II in obesity.

  Body weight is controlled by the activation of signal transduction pathways in both the brain and peripheral tissues. Interestingly, although many hyp…

  Authors: Enxuan Jing, Eduardo A Nillni, Vanesa C Sanchez, Ronald C Stuart, Deborah J Good

  Source: Endocrinology. 2004 Apr

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• SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.

  The family of mammalian Sirtuin proteins comprises seven members homologous to yeast Sir2. Here we show that SIRT2, a cytoplasmic sirtuin, is the most…

  Authors: Enxuan Jing, Stephane Gesta, C Ronald Kahn

  Source: Cell metabolism. 2007 Aug

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• Reduced voluntary activity precedes adult-onset obesity in Nhlh2 knockout mice.

  Targeted deletion of the neuronal basic helix-loop-helix transcription factor Nhlh2 results in adult-onset obesity in mice. Measurement of body weight…

  Authors: Christopher A Coyle, Enxuan Jing, Trina Hosmer, J Bradley Powers, George Wade, Deborah J Good

  Source: Physiology & behavior. 2002 Nov

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