1 to 10 of 20 literature results

• Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

  Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL…

  Authors: Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,…

  Source: Nature medicine. 2009 Jan

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• Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas.

  The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistro…

  Authors: Ping Mu, Yoon-Chi Han, Doron Betel, Evelyn Yao, Massimo Squatrito, Paul Ogrodowski, Elisa de Stanchina, Aleco D'Andrea, Chris Sander, Andrea Ventura

  Source: Genes & development. 2009 Dec 15

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• A microRNA component of the p53 tumour suppressor network.

  A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour s…

  Authors: Lin He, Xingyue He, Lee P Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon,…

  Source: Nature. 2007 Jun 28

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• Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.

  Evading apoptosis is considered to be a hallmark of cancer, because mutations in apoptotic regulators invariably accompany tumorigenesis. Many chemoth…

  Authors: Hans-Guido Wendel, Elisa De Stanchina, Jordan S Fridman, Abba Malina, Sagarika Ray, Scott Kogan, Carlos Cordon-Cardo, Jerry Pelletier, Scott W Lowe

  Source: Nature. 2004 Mar 18

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• Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

  Spinal muscular atrophy is a neurodegenerative disorder caused by the deletion or mutation of the survival-of-motor-neuron gene, SMN1. An SMN1 paralog…

  Authors: Luca Cartegni, Michelle L Hastings, John A Calarco, Elisa de Stanchina, Adrian R Krainer

  Source: American journal of human genetics. 2006 Jan

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• PML is a direct p53 target that modulates p53 effector functions.

  The p53 tumor suppressor promotes cell cycle arrest or apoptosis in response to stress. Previous work suggests that the promyelocytic leukemia gene (P…

  Authors: Elisa de Stanchina, Emmanuelle Querido, Masako Narita, Ramana V Davuluri, Pier Paolo Pandolfi, Gerardo Ferbeyre, Scott W Lowe

  Source: Molecular cell. 2004 Feb 27

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• The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.

  The insulin-like growth factor 1 (IGF-1)-AKT-mTOR pathways sense the availability of nutrients and mitogens and respond by signaling for cell growth a…

  Authors: Zhaohui Feng, Wenwei Hu, Elisa de Stanchina, Angelika K Teresky, Shengkan Jin, Scott Lowe, Arnold J Levine

  Source: Cancer research. 2007 Apr 1

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• Stepwise neoplastic transformation of a telomerase immortalized fibroblast cell line.

  We have described recently a human fibroblast cell line immortalized through ectopic telomerase expression (cen3tel), in which the extension of the li…

  Authors: Samantha Zongaro, Elisa de Stanchina, Tina Colombo, Maurizio D'Incalci, Elena Giulotto, Chiara Mondello

  Source: Cancer research. 2005 Dec 15

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• Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

  PURPOSE: Intra-arterial delivery of chemotherapeutic agents offers a new and exciting opportunity for the treatment of advanced intraocular retinoblas…

  Authors: Christophe Antczak, Carolyn Kloepping, Constantin Radu, Thorsten Genski, Lutz Müller-Kuhrt, Karsten Siems, Elisa de Stanchina, David H Abramson, Hakim Djaballah

  Source: Investigative ophthalmology & visual science. 2009 Jul

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• Tumour suppression: something for nothing?

  Authors: Elisa de Stanchina, Scott W Lowe

  Source: Nature cell biology. 2002 Dec

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