1 to 10 of 13 literature results

• Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

  Phosphoinositide-dependent kinase-1 (PDK1) is implicated in the metabolic effects of insulin as a key mediator of phosphoinositide 3-kinase-dependent …

  Authors: Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue,…

  Source: Diabetes. 2007 Apr

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• Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver.

  Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T l…

  Authors: Sachie Nakamichi, Yoko Senga, Hiroshi Inoue, Aki Emi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa, Masato Kasuga

  Source: Journal of molecular endocrinology. 2009 Feb

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• The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes.

  KLF15 (Krüppel-like factor 15) plays a key role in adipocyte differentiation and glucose transport in adipocytes through activation of its target gene…

  Authors: Tomoki Nagare, Hiroshi Sakaue, Mototsugu Takashima, Kazuhiro Takahashi, Hideyuki Gomi, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Wataru Ogawa, Masato Kasuga

  Source: Biochemical and biophysical research communications. 2009 Jan 30

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• Identification and characterization of an alternative promoter of the human PGC-1alpha gene.

  The transcriptional regulator peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) controls mitochondrial biogenesis and e…

  Authors: Toyo Yoshioka, Kenjiro Inagaki, Tetsuya Noguchi, Mashito Sakai, Wataru Ogawa, Tetsuya Hosooka, Haruhisa Iguchi, Eijiro Watanabe, Yasushi Matsuki, Ryuji Hiramatsu,…

  Source: Biochemical and biophysical research communications. 2009 Apr 17

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• Skp2 promotes adipocyte differentiation via a p27Kip1-independent mechanism in primary mouse embryonic fibroblasts.

  Skp2, the substrate-binding subunit of an SCF ubiquitin ligase complex, is a key regulator of cell cycle progression that targets substrates for degra…

  Authors: Mitsuru Okada, Tamon Sakai, Takehiro Nakamura, Mimi Tamamori-Adachi, Shigetaka Kitajima, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue, Masato Kasuga

  Source: Biochemical and biophysical research communications. 2009 Feb 6

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• Role of Krüppel-like factor 15 in PEPCK gene expression in the liver.

  Regulation of hepatic gene expression is important for energy homeostasis. We now show that hepatic expression of the gene for the transcription facto…

  Authors: Kiyoshi Teshigawara, Wataru Ogawa, Toshiyuki Mori, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Inoue, Kazuaki Miyake, Hiroshi Sakaue, Masato Kasuga

  Source: Biochemical and biophysical research communications. 2005 Feb 18

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• Role of hepatic STAT3 in the regulation of lipid metabolism.

  Regulation of hepatic gene expression is largely responsible for the control of nutrient metabolism. We previously showed that the transcription facto…

  Authors: Shinichi Kinoshita, Wataru Ogawa, Yasuo Okamoto, Mototsugu Takashima, Hiroshi Inoue, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Masato Kasuga

  Source: The Kobe journal of medical sciences. 2008

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• Skp2 controls adipocyte proliferation during the development of obesity.

  The increase in the mass of adipose tissue during the development of obesity can arise through an increase in cell size, an increase in cell number, o…

  Authors: Tamon Sakai, Hiroshi Sakaue, Takehiro Nakamura, Mitsuru Okada, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Keiko Nakayama, Keiichi I Nakayama, Masato Kasuga

  Source: The Journal of biological chemistry. 2007 Jan 19

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• PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression.

  PDK1 (3-phosphoinositide-dependent protein kinase 1) is a key mediator of signaling by phosphoinositide 3-kinase. To gain insight into the physiologic…

  Authors: Kyoko Nakamura, Hiroshi Sakaue, Akihiko Nishizawa, Yasushi Matsuki, Hideyuki Gomi, Eijiro Watanabe, Ryuji Hiramatsua, Mimi Tamamori-Adachi, Shigetaka Kitajima, Tetsuo Noda,…

  Source: The Journal of biological chemistry. 2008 Jun 20

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• Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.

  STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes in the liver. The mechanism by which hepatic STAT3 is regulat…

  Authors: Hiroshi Inoue, Wataru Ogawa, Akihiro Asakawa, Yasuo Okamoto, Akihiko Nishizawa, Michihiro Matsumoto, Kiyoshi Teshigawara, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu,…

  Source: Cell metabolism. 2006 Apr

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