1 to 10 of 16 literature results

• Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.

  This paper is not a comprehensive review of the literature. Rather, it is a viewpoint based upon advances in other fields of medicine and genetics tha…

  Authors: Edward M Scolnick

  Source: Biological psychiatry. 2006 Jun 1

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.

  DTNBP1 was first identified as a putative schizophrenia-susceptibility gene in Irish pedigrees, with a report of association to common genetic variati…

  Authors: Mousumi Mutsuddi, Derek W Morris, Skye G Waggoner, Mark J Daly, Edward M Scolnick, Pamela Sklar

  Source: American journal of human genetics. 2006 Nov

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• Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.

  Lithium inhibits inositol monophosphatase at therapeutically effective concentrations, and it has been hypothesized that depletion of brain inositol l…

  Authors: Philip E Brandish, Ming Su, Daniel J Holder, Paul Hodor, John Szumiloski, Robert R Kleinhanz, Jaime E Forbes, Mollie E McWhorter, Sven J Duenwald, Mark L Parrish,…

  Source: Neuron. 2005 Mar 24

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• Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company.

  Authors: Edward M Scolnick

  Source: Biological psychiatry. 2002 Aug 1

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• Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation.

  The phosphatidylinositol turnover assay is used widely to measure activation, and inhibition, of G(q)-linked G-protein-coupled receptors. Cells expres…

  Authors: Philip E Brandish, Lorraine A Hill, Wei Zheng, Edward M Scolnick

  Source: Analytical biochemistry. 2003 Feb 15

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• The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.

  A potent and selective anthrax LF inhibitor 40, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, was i…

  Authors: Yusheng Xiong, Judyann Wiltsie, Andrea Woods, Jian Guo, James V Pivnichny, Wei Tang, Alka Bansal, Richard T Cummings, Barry R Cunningham, Arthur M Friedlander,…

  Source: Bioorganic & medicinal chemistry letters. 2006 Feb 15

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• Developing novel treatments for mood disorders: accelerating discovery.

  This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Pl…

  Authors: Carol A Tamminga, Charles B Nemeroff, Randy D Blakely, Linda Brady, Cameron S Carter, Kenneth L Davis, Raymond Dingledine, Jack M Gorman, Dimitri E Grigoriadis, David C Henderson,…

  Source: Biological psychiatry. 2002 Sep 15

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• Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?

  The sequencing of the human genome and an emerging dense map of markers across the human genome have spawned new approaches to search for risk genes f…

  Authors: Edward M Scolnick, Tracey Petryshen, Pamela Sklar

  Source: Harvard review of psychiatry. 2006 Mar-Apr

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• Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

  Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within t…

  Authors: Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler,…

  Source: PLoS genetics. 2009 Jun

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