1 to 10 of 80 literature results

• Genomics of cellulosic biofuels.

  The development of alternatives to fossil fuels as an energy source is an urgent global priority. Cellulosic biomass has the potential to contribute t…

  Authors: Edward M Rubin

  Source: Nature. 2008 Aug 14

  View Full Text

• Genomic views of distant-acting enhancers.

  In contrast to protein-coding sequences, the significance of variation in non-coding DNA in human disease has been minimally explored. A great number …

  Authors: Axel Visel, Edward M Rubin, Len A Pennacchio

  Source: Nature. 2009 Sep 10

  View Full Text

• ChIP-seq accurately predicts tissue-specific activity of enhancers.

  A major yet unresolved quest in decoding the human genome is the identification of the regulatory sequences that control the spatial and temporal expr…

  Authors: Axel Visel, Matthew J Blow, Zirong Li, Tao Zhang, Jennifer A Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen,…

  Source: Nature. 2009 Feb 12

  View Full Text

• Ultraconservation identifies a small subset of extremely constrained developmental enhancers.

  Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional…

  Authors: Axel Visel, Shyam Prabhakar, Jennifer A Akiyama, Malak Shoukry, Keith D Lewis, Amy Holt, Ingrid Plajzer-Frick, Veena Afzal, Edward M Rubin, Len A Pennacchio

  Source: Nature genetics. 2008 Feb

  View Free Full Text

• A distal enhancer and an ultraconserved exon are derived from a novel retroposon.

  Hundreds of highly conserved distal cis-regulatory elements have been characterized so far in vertebrate genomes. Many thousands more are predicted on…

  Authors: Gill Bejerano, Craig B Lowe, Nadav Ahituv, Bryan King, Adam Siepel, Sofie R Salama, Edward M Rubin, W James Kent, David Haussler

  Source: Nature. 2006 May 4

  View Full Text

• Symbiosis insights through metagenomic analysis of a microbial consortium.

  Symbioses between bacteria and eukaryotes are ubiquitous, yet our understanding of the interactions driving these associations is hampered by our inab…

  Authors: Tanja Woyke, Hanno Teeling, Natalia N Ivanova, Marcel Huntemann, Michael Richter, Frank Oliver Gloeckner, Dario Boffelli, Iain J Anderson, Kerrie W Barry, Harris J Shapiro,…

  Source: Nature. 2006 Oct 26

  View Full Text

• Megabase deletions of gene deserts result in viable mice.

  The functional importance of the roughly 98% of mammalian genomes not corresponding to protein coding sequences remains largely undetermined. Here we …

  Authors: Marcelo A Nóbrega, Yiwen Zhu, Ingrid Plajzer-Frick, Veena Afzal, Edward M Rubin

  Source: Nature. 2004 Oct 21

  View Full Text

• The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.

  In mice, the Ter mutation causes primordial germ cell (PGC) loss in all genetic backgrounds. Ter is also a potent modifier of spontaneous testicular g…

  Authors: Kirsten K Youngren, Douglas Coveney, Xiaoning Peng, Chitralekha Bhattacharya, Laura S Schmidt, Michael L Nickerson, Bruce T Lamb, Jian Min Deng, Richard R Behringer, Blanche Capel,…

  Source: Nature. 2005 May 19

  View Free Full Text

• In vivo enhancer analysis of human conserved non-coding sequences.

  Identifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge…

  Authors: Len A Pennacchio, Nadav Ahituv, Alan M Moses, Shyam Prabhakar, Marcelo A Nobrega, Malak Shoukry, Simon Minovitsky, Inna Dubchak, Amy Holt, Keith D Lewis,…

  Source: Nature. 2006 Nov 23

  View Full Text

• Community structure and metabolism through reconstruction of microbial genomes from the environment.

  Microbial communities are vital in the functioning of all ecosystems; however, most microorganisms are uncultivated, and their roles in natural system…

  Authors: Gene W Tyson, Jarrod Chapman, Philip Hugenholtz, Eric E Allen, Rachna J Ram, Paul M Richardson, Victor V Solovyev, Edward M Rubin, Daniel S Rokhsar, Jillian F Banfield

  Source: Nature. 2004 Mar 4

  View Full Text