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Mammalian nicotinic acetylcholine receptors: from structure to function.
The classical studies of nicotine by Langley at the turn of the 20th century introduced the concept of a "receptive substance," from which the idea of…
Authors: Edson X Albuquerque, Edna F R Pereira, Manickavasagom Alkondon, Scott W Rogers
Source: Physiological reviews. 2009 Jan
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An acute exposure to a sub-lethal dose of soman triggers anxiety-related behavior in guinea pigs: interactions with acute restraint.
In this study, we tested the hypothesis that a single exposure of guinea pigs to sub-lethal doses of soman triggers anxiety-related behavior that is m…
Authors: Jacek Mamczarz, Edna F R Pereira, Yasco Aracava, Michael Adler, Edson X Albuquerque
Source: Neurotoxicology. 2010 Jan
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Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus.
Protein density measurements and mRNA analysis have provided valuable information on age-dependent changes in the distribution of different nicotinic …
Authors: Manickavasagom Alkondon, Edna F R Pereira, Edson X Albuquerque
Source: Biochemical pharmacology. 2007 Oct 15
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Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley.
Prepulse inhibition (PPI), a measure of sensorimotor gating impaired in patients with schizophrenia, is more sensitive to disruption by apomorphine in…
Authors: Manickavasagom Alkondon, Edna F R Pereira, Michelle C Potter, Frederick C Kauffman, Robert Schwarcz, Edson X Albuquerque
Source: Journal of neurophysiology. 2007 Feb
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Magnetic resonance imaging reveals that galantamine prevents structural brain damage induced by an acute exposure of guinea pigs to soman.
Galantamine, a drug used to treat Alzheimer's disease, has recently emerged as a potential medical countermeasure against the toxicity of organophosph…
Authors: Rao P Gullapalli, Yasco Aracava, Jiachen Zhuo, Edward Helal Neto, Jiazheng Wang, George Makris, Istvan Merchenthaler, Edna F R Pereira, Edson X Albuquerque
Source: Neurotoxicology. 2010 Jan
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NMDA and AMPA receptors contribute to the nicotinic cholinergic excitation of CA1 interneurons in the rat hippocampus.
In the hippocampus, glutamatergic inputs to pyramidal neurons and interneurons are modulated by alpha7* and alpha3beta4* nicotinic acetylcholine recep…
Authors: Manickavasagom Alkondon, Edna F R Pereira, Edson X Albuquerque
Source: Journal of neurophysiology. 2003 Sep
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The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system.
In this study, the patch-clamp technique was used to determine the effects of galantamine, a cholinesterase inhibitor and a nicotinic allosteric poten…
Authors: Máriton D Santos, Manickavasagom Alkondon, Edna F R Pereira, Yasco Aracava, Howard M Eisenberg, Alfred Maelicke, Edson X Albuquerque
Source: Molecular pharmacology. 2002 May
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Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.
In HEK293 cells stably expressing alpha4beta2 nAChRs, naltrexone, but not naloxone, blocked alpha4beta2 nAChRs via an open-channel blocking mechanism.…
Authors: Luis E F Almeida, Edna F R Pereira, Adriana L Camara, Alfred Maelicke, Edson X Albuquerque
Source: Bioorganic & medicinal chemistry letters. 2004 Apr 19
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Herpes simplex virus type 1-induced encephalitis has an apoptotic component associated with activation of c-Jun N-terminal kinase.
Herpes simplex virus type 1 (HSV-1) triggered apoptosis in hippocampal cultures, as determined by terminal deoxynucleotidyl transferase-mediated dUTP …
Authors: Dana Perkins, Kymberly A Gyure, Edna F R Pereira, Laure Aurelian
Source: Journal of neurovirology. 2003 Feb
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Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition.
This study was designed to test the hypothesis that the acute toxicity of the nerve agents S-[2-(diisopropylamino)ethyl]-O-ethyl methylphosphonothioat…
Authors: William P Fawcett, Yasco Aracava, Michael Adler, Edna F R Pereira, Edson X Albuquerque
Source: The Journal of pharmacology and experimental therapeutics. 2009 Feb
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