1 to 10 of 900 literature results

• Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.

  Production of bile by the liver is crucial for the absorption of lipophilic nutrients. Dysregulation of bile acid homeostasis can lead to cholestatic …

  Authors: Irina M Bochkis, Nir E Rubins, Peter White, Emma E Furth, Joshua R Friedman, Klaus H Kaestner

  Source: Nature medicine. 2008 Aug

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• MtDNA mutation pattern in tumors and human evolution are shaped by similar selective constraints.

  Multiple human mutational landscapes of normal and cancer conditions are currently available. However, while the unique mutational patterns of tumors …

  Authors: Ilia Zhidkov, Erez A Livneh, Eitan Rubin, Dan Mishmar

  Source: Genome research. 2009 Apr

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• Regulation of cancer cell migration and bone metastasis by RANKL.

  Bone metastases are a frequent complication of many cancers that result in severe disease burden and pain. Since the late nineteenth century, it has b…

  Authors: D Holstead Jones, Tomoki Nakashima, Otto H Sanchez, Ivona Kozieradzki, Svetlana V Komarova, Ildiko Sarosi, Sean Morony, Evelyn Rubin, Renu Sarao, Carlo V Hojilla,…

  Source: Nature. 2006 Mar 30

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• Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling.

  Soft tissue sarcomas (STS) have a strong propensity for aggressive growth and metastasis. We showed that the secreted Wnt antagonist Frzb exhibited po…

  Authors: Yi Guo, Jun Xie, Elyssa Rubin, Ya-Xiong Tang, Fritz Lin, Xiaolin Zi, Bang H Hoang

  Source: Cancer research. 2008 May 1

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• Comparative cross-species alternative splicing in plants.

  Alternative splicing (AS) can add significantly to genome complexity. Plants are thought to exhibit less AS than animals. An algorithm, based on expre…

  Authors: Hadas Ner-Gaon, Noam Leviatan, Eitan Rubin, Robert Fluhr

  Source: Plant physiology. 2007 Jul

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• Foxa2-dependent hepatic gene regulatory networks depend on physiological state.

  Bile acids are powerful detergents produced by the liver to aid in the absorption of dietary lipids. We recently reported a novel role for Foxa2 in bi…

  Authors: Irina M Bochkis, Jonathan Schug, Nir E Rubins, Atul R Chopra, Bert W O'Malley, Klaus H Kaestner

  Source: Physiological genomics. 2009 Jul 9

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• Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis.

  Central pattern generators (CPGs) consisting of interacting groups of neurons drive a variety of repetitive, rhythmic behaviors in invertebrates and v…

  Authors: Silvia Daun, Jonathan E Rubin, Ilya A Rybak

  Source: Journal of computational neuroscience. 2009 Aug

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• Multiple rhythmic states in a model of the respiratory central pattern generator.

  The three-phase respiratory pattern observed during normal breathing changes with alterations in metabolic or physiological conditions. A recent study…

  Authors: Jonathan E Rubin, Natalia A Shevtsova, G Bard Ermentrout, Jeffrey C Smith, Ilya A Rybak

  Source: Journal of neurophysiology. 2009 Apr

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• Growth of pulmonary microvasculature in ventilated preterm infants.

  RATIONALE: Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BP…

  Authors: Monique E De Paepe, Quanfu Mao, Jessica Powell, Sam E Rubin, Philip DeKoninck, Naomi Appel, Meredith Dixon, Füsun Gundogan

  Source: American journal of respiratory and critical care medicine. 2006 Jan 15

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• HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition.

  Epithelial-mesenchymal transition (EMT) is increasingly recognized as a mechanism whereby cells in primary noninvasive tumors acquire properties essen…

  Authors: Xinyan Wu, Hexin Chen, Belinda Parker, Ethel Rubin, Tao Zhu, Ji Shin Lee, Pedram Argani, Saraswati Sukumar

  Source: Cancer research. 2006 Oct 1

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