1 to 10 of 13 literature results

• Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins.

  A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used…

  Authors: Sandip Ray, Markus Britschgi, Charles Herbert, Yoshiko Takeda-Uchimura, Adam Boxer, Kaj Blennow, Leah F Friedman, Douglas R Galasko, Marek Jutel, Anna Karydas,…

  Source: Nature medicine. 2007 Nov

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• Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates.

  Amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) is a fatal neurodegenerative disease found in the Chamorro people of Guam and ot…

  Authors: Weiva Sieh, Yoonha Choi, Nicola H Chapman, Ulla-Katrina Craig, Ellen J Steinbart, Joseph H Rothstein, Kiyomitsu Oyanagi, Ralph M Garruto, Thomas D Bird, Douglas R Galasko,…

  Source: Human molecular genetics. 2009 Oct 1

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• Two sites in the MAPT region confer genetic risk for Guam ALS/PDC and dementia.

  Unusual forms of amyotrophic lateral sclerosis (ALS-G), Parkinsonism dementia complex (PDC-G) and Guam dementia (GD) are found in Chamorros, the indig…

  Authors: Purnima Desai Sundar, Chang-En Yu, Weiva Sieh, Ellen Steinbart, Ralph M Garruto, Kiyomitsu Oyanagi, Ulla-Katrina Craig, Thomas D Bird, Ellen M Wijsman, Douglas R Galasko,…

  Source: Human molecular genetics. 2007 Feb 1

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• Reduction of SorLA/LR11, a sorting protein limiting beta-amyloid production, in Alzheimer disease cerebrospinal fluid.

  BACKGROUND: The sortilin-related receptor SorLA/LR11 (LR11) is a transmembrane neuronal sorting protein that reduces beta-amyloid precursor protein tr…

  Authors: Qiu-Lan Ma, Douglas R Galasko, John M Ringman, Harry V Vinters, Steven D Edland, Justine Pomakian, Oliver J Ubeda, Emily R Rosario, Bruce Teter, Sally A Frautschy,…

  Source: Archives of neurology. 2009 Apr

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• The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.

  BACKGROUND: Mutation in the progranulin gene (GRN) can cause frontotemporal dementia (FTD). However, it is unclear whether some rare FTD-related GRN v…

  Authors: Chang-En Yu, Thomas D Bird, Lynn M Bekris, Thomas J Montine, James B Leverenz, Ellen Steinbart, Nichole M Galloway, Howard Feldman, Randall Woltjer, Carol A Miller,…

  Source: Archives of neurology. 2010 Feb

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• Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition.

  BACKGROUND: Decreased cerebrospinal fluid (CSF) beta-amyloid 42 (A beta 42) concentration, but not A beta 40 concentration, is a biomarker for Alzheim…

  Authors: Elaine R Peskind, Ge Li, Jane Shofer, Joseph F Quinn, Jeffrey A Kaye, Chris M Clark, Martin R Farlow, Charles DeCarli, Murray A Raskind, Gerard D Schellenberg,…

  Source: Archives of neurology. 2006 Jul

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• Verbal learning and memory in patients with dementia with Lewy bodies or Parkinson's disease with dementia.

  This study compared verbal learning and memory in patients with autopsy-confirmed dementia with Lewy bodies (DLB) and patients with Parkinson's diseas…

  Authors: J Vincent Filoteo, David P Salmon, Dawn M Schiehser, Amy E Kane, Joanne M Hamilton, Laurie M Rilling, John A Lucas, Vanessa Zizak, Douglas R Galasko

  Source: Journal of clinical and experimental neuropsychology. 2009 Oct

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• TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.

  BACKGROUND: TDP-43 is a major component of the ubiquitinated inclusions that characterise amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…

  Authors: Vivianna M Van Deerlin, James B Leverenz, Lynn M Bekris, Thomas D Bird, Wuxing Yuan, Lauren B Elman, Dana Clay, Elisabeth McCarty Wood, Alice S Chen-Plotkin, Maria Martinez-Lage,…

  Source: Lancet neurology. 2008 May

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• Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.

  BACKGROUND: Mild cognitive impairment (MCI) represents a transitional state between the cognitive changes of normal aging and very early dementia and …

  Authors: Michael Grundman, Ronald C Petersen, Steven H Ferris, Ronald G Thomas, Paul S Aisen, David A Bennett, Norman L Foster, Clifford R Jack, Douglas R Galasko, Rachelle Doody,…

  Source: Archives of neurology. 2004 Jan

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• Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.

  BACKGROUND: Brain-derived neurotrophic factor (BDNF) is an activity-dependent secreted protein that is critical to organization of neuronal networks a…

  Authors: Ge Li, Elaine R Peskind, Steven P Millard, Peter Chi, Izabela Sokal, Chang-En Yu, Lynn M Bekris, Murray A Raskind, Douglas R Galasko, Thomas J Montine

  Source: PloS one. 2009

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