1 to 10 of 11 literature results

• Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae.

  Comprehensive identification of polymorphisms among individuals within a species is essential both for studying the genetic basis of phenotypic differ…

  Authors: Joseph Schacherer, Joshua A Shapiro, Douglas M Ruderfer, Leonid Kruglyak

  Source: Nature. 2009 Mar 19

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• Population genomic analysis of outcrossing and recombination in yeast.

  The budding yeast Saccharomyces cerevisiae has been used by humans for millennia to make wine, beer and bread. More recently, it became a key model or…

  Authors: Douglas M Ruderfer, Stephen C Pratt, Hannah S Seidel, Leonid Kruglyak

  Source: Nature genetics. 2006 Sep

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• Genetic basis of individual differences in the response to small-molecule drugs in yeast.

  Individual response to small-molecule drugs is variable; a drug that provides a cure for some may confer no therapeutic benefit or trigger an adverse …

  Authors: Ethan O Perlstein, Douglas M Ruderfer, David C Roberts, Stuart L Schreiber, Leonid Kruglyak

  Source: Nature genetics. 2007 Apr

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• Genetic basis of proteome variation in yeast.

  Proper regulation of protein levels is essential for health, and abnormal levels of proteins are hallmarks of many diseases. A number of studies have …

  Authors: Eric J Foss, Dragan Radulovic, Scott A Shaffer, Douglas M Ruderfer, Antonio Bedalov, David R Goodlett, Leonid Kruglyak

  Source: Nature genetics. 2007 Nov

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Revealing complex traits with small molecules and naturally recombinant yeast strains.

  Here we demonstrate that natural variants of the yeast Saccharomyces cerevisiae are a model system for the systematic study of complex traits, specifi…

  Authors: Ethan O Perlstein, Douglas M Ruderfer, Gopal Ramachandran, Stephen J Haggarty, Leonid Kruglyak, Stuart L Schreiber

  Source: Chemistry & biology. 2006 Mar

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• Using expression and genotype to predict drug response in yeast.

  Personalized, or genomic, medicine entails tailoring pharmacological therapies according to individual genetic variation at genomic loci encoding prot…

  Authors: Douglas M Ruderfer, David C Roberts, Stuart L Schreiber, Ethan O Perlstein, Leonid Kruglyak

  Source: PloS one. 2009

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• Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains.

  Ten years have passed since the genome of Saccharomyces cerevisiae-more precisely, the S288c strain-was completely sequenced. However, experimental wo…

  Authors: Joseph Schacherer, Douglas M Ruderfer, David Gresham, Kara Dolinski, David Botstein, Leonid Kruglyak

  Source: PloS one. 2007

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• Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.

  Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We fo…

  Authors: Tonibelle Gatbonton, Maria Imbesi, Melisa Nelson, Joshua M Akey, Douglas M Ruderfer, Leonid Kruglyak, Julian A Simon, Antonio Bedalov

  Source: PLoS genetics. 2006 Mar

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• Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray.

  A central challenge of genomics is to detect, simply and inexpensively, all differences in sequence among the genomes of individual members of a speci…

  Authors: David Gresham, Douglas M Ruderfer, Stephen C Pratt, Joseph Schacherer, Maitreya J Dunham, David Botstein, Leonid Kruglyak

  Source: Science (New York, N.Y.). 2006 Mar 31

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