1 to 10 of 62 literature results

• Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice.

  BACKGROUND: Immunoglobulin M (IgM) natural antibodies bind oxidatively-modified low-density lipoprotein (LDL) and apoptotic cells and have been implic…

  Authors: Myles J Lewis, Talat H Malik, Michael R Ehrenstein, Joseph J Boyle, Marina Botto, Dorian O Haskard

  Source: Circulation. 2009 Aug 4

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• Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1/2.

  Antiendothelial cell antibodies (AECAs) are commonly detectable in diseases associated with vascular injury, including systemic lupus erythematosus (S…

  Authors: Oliver J Florey, Michael Johns, Olubukola O Esho, Justin C Mason, Dorian O Haskard

  Source: Blood. 2007 May 1

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• The role of complement in atherosclerosis.

  PURPOSE OF REVIEW: Although it has long been recognized that atherosclerotic lesions show evidence of complement activation, the functional roles of t…

  Authors: Dorian O Haskard, Joseph J Boyle, Justin C Mason

  Source: Current opinion in lipidology. 2008 Oct

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• Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin.

  Tight regulation of the balance between apoptosis and survival is essential in angiogenesis. The ETS transcription factor Erg is required for endothel…

  Authors: Graeme M Birdsey, Nicola H Dryden, Valerie Amsellem, Frank Gebhardt, Kapil Sahnan, Dorian O Haskard, Elisabetta Dejana, Justin C Mason, Anna M Randi

  Source: Blood. 2008 Apr 1

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• Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin.

  Catabolism of free heme by heme oxygenase-1 (HO-1) generates carbon monoxide, biliverdin, and free iron (Fe). These end-products are responsible for m…

  Authors: Anne R Kinderlerer, Isabel Pombo Gregoire, Shahir S Hamdulay, Faisal Ali, Rivka Steinberg, Gabriela Silva, Nadira Ali, Bufei Wang, Dorian O Haskard, Miguel P Soares,…

  Source: Blood. 2009 Feb 12

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• PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress.

  AIMS: Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily of ligand-activated transcriptional regulato…

  Authors: Faisal Ali, Nadira S Ali, Andrea Bauer, Joseph J Boyle, Shahir S Hamdulay, Dorian O Haskard, Anna M Randi, Justin C Mason

  Source: Cardiovascular research. 2010 Mar 1

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• ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.

  ICAM-2 has been implicated in leukocyte transmigration in vitro, but there is little in vivo evidence to support this. To address this, neutrophil mig…

  Authors: Miao-Tzu Huang, Karen Y Larbi, Christoph Scheiermann, Abigail Woodfin, Nicole Gerwin, Dorian O Haskard, Sussan Nourshargh

  Source: Blood. 2006 Jun 15

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• JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.

  Junctional adhesion molecule-A (JAM-A) is a transmembrane protein expressed at tight junctions of endothelial and epithelial cells and on the surface …

  Authors: Abigail Woodfin, Christoph Andreas Reichel, Andrej Khandoga, Monica Corada, Mathieu-Benoit Voisin, Christoph Scheiermann, Dorian O Haskard, Elisabetta Dejana, Fritz Krombach, Sussan Nourshargh

  Source: Blood. 2007 Sep 15

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• Shedding of lymphocyte function-associated antigen-1 (LFA-1) in a human inflammatory response.

  Shedding of adhesion molecules has been described for members of the selectin and immunoglobulin superfamilies, but integrins are not known to be shed…

  Authors: Betsy J Evans, Alison McDowall, Peter C Taylor, Nancy Hogg, Dorian O Haskard, R Clive Landis

  Source: Blood. 2006 May 1

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• Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.

  Atherosclerosis is a chronic inflammatory disease of arteries. It is triggered by proinflammatory mediators which induce adhesion molecules (eg, vascu…

  Authors: Mustafa Zakkar, Hera Chaudhury, Gunhild Sandvik, Karine Enesa, Le Anh Luong, Simon Cuhlmann, Justin C Mason, Rob Krams, Andrew R Clark, Dorian O Haskard,…

  Source: Circulation research. 2008 Sep 26

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