1 to 5 of 5 literature results

• Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism.

  Lenalidomide and pomalidomide have both been evaluated clinically for their properties as anticancer agents, with lenalidomide being available commerc…

  Authors: Laure Escoubet-Lozach, I-Lin Lin, Kristen Jensen-Pergakes, Helen A Brady, Anita K Gandhi, Peter H Schafer, George W Muller, Peter J Worland, Kyle W H Chan, Dominique Verhelle

  Source: Cancer research. 2009 Sep 15

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• Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells.

  Clinical studies involving patients with myelodysplastic syndromes or multiple myeloma have shown the efficacy of lenalidomide by reducing and often e…

  Authors: Dominique Verhelle, Laura G Corral, Kevin Wong, Jessica H Mueller, Laure Moutouh-de Parseval, Kristen Jensen-Pergakes, Peter H Schafer, Roger Chen, Emilia Glezer, Gregory D Ferguson,…

  Source: Cancer research. 2007 Jan 15

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• Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2.

  COX2 (prostaglandin G/H synthase, PTGS2) is a well-validated target in the fields of both oncology and inflammation. Despite their significant toxicit…

  Authors: Gregory D Ferguson, Kristen Jensen-Pergakes, Candice Wilkey, Urvi Jhaveri, Normand Richard, Dominique Verhelle, Laure Moutouh De Parseval, Laura G Corral, Weilin Xie, Christopher L Morris,…

  Source: Journal of clinical immunology. 2007 Mar

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• Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells.

  Sickle-cell disease (SCD) and beta thalassemia constitute worldwide public health problems. New therapies, including hydroxyurea, have attempted to au…

  Authors: Laure A Moutouh-de Parseval, Dominique Verhelle, Emilia Glezer, Kristen Jensen-Pergakes, Gregory D Ferguson, Laura G Corral, Christopher L Morris, George Muller, Helen Brady, Kyle Chan

  Source: The Journal of clinical investigation. 2008 Jan

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• Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.

  The molecular mechanisms that control the proliferation and differentiation of specific cell types remain poorly understood. Positive ETS factors play…

  Authors: Kelly D Hester, Dominique Verhelle, Laure Escoubet-Lozach, Rosa Luna, David W Rose, Christopher K Glass

  Source: Cell cycle (Georgetown, Tex.). 2007 Jul 1

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