1 to 10 of 92 literature results

• Aire.

  Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECE…

  Authors: Diane Mathis, Christophe Benoist

  Source: Annual review of immunology. 2009

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• Foxp3+ regulatory T cells: differentiation, specification, subphenotypes.

  Regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a m…

  Authors: Markus Feuerer, Jonathan A Hill, Diane Mathis, Christophe Benoist

  Source: Nature immunology. 2009 Jul

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• Treg cells: guardians for life.

  Regulatory T cells expressing the transcription factor Foxp3 are known to control autoreactivity during and subsequent to the development of the perip…

  Authors: Jonathan A Hill, Christophe Benoist, Diane Mathis

  Source: Nature immunology. 2007 Feb

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• Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.

  Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings rai…

  Authors: Markus Feuerer, Laura Herrero, Daniela Cipolletta, Afia Naaz, Jamie Wong, Ali Nayer, Jongsoon Lee, Allison B Goldfine, Christophe Benoist, Steven Shoelson,…

  Source: Nature medicine. 2009 Aug

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• How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.

  CD4(+)Foxp3(+) regulatory T cells (Treg cells) are known to control the progression of autoimmune diabetes, but when, where, and how they exert their …

  Authors: Markus Feuerer, Yuelei Shen, Dan R Littman, Christophe Benoist, Diane Mathis

  Source: Immunity. 2009 Oct 16

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• Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.

  Thymocytes displaying self-reactive T cell receptors usually undergo negative selection in the thymus. Here we demonstrate that agonist peptides can p…

  Authors: Tetsuya Yamagata, Diane Mathis, Christophe Benoist

  Source: Nature immunology. 2004 Jun

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• Particularities of the vasculature can promote the organ specificity of autoimmune attack.

  How certain autoimmune diseases target specific organs remains obscure. In the 'K/BxN' arthritis model, autoantibodies to a ubiquitous antigen elicit …

  Authors: Bryce A Binstadt, Pratik R Patel, Herlen Alencar, Peter A Nigrovic, David M Lee, Umar Mahmood, Ralph Weissleder, Diane Mathis, Christophe Benoist

  Source: Nature immunology. 2006 Mar

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• Mast cells in autoimmune disease.

  Mast cells are known to be the primary responders in allergic reactions, orchestrating strong responses to minute amounts of allergens. Several recent…

  Authors: Christophe Benoist, Diane Mathis

  Source: Nature. 2002 Dec 19-26

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• Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

  CD4(+)Foxp3(+) regulatory T (Treg) cells originate primarily from thymic differentiation, but conversion of mature T lymphocytes to Foxp3 positivity c…

  Authors: Jonathan A Hill, Jason A Hall, Cheng-Ming Sun, Qi Cai, Norbert Ghyselinck, Pierre Chambon, Yasmine Belkaid, Diane Mathis, Christophe Benoist

  Source: Immunity. 2008 Nov 14

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• Back to central tolerance.

  The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the p…

  Authors: Diane Mathis, Christophe Benoist

  Source: Immunity. 2004 May

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