1 to 4 of 4 literature results

• Separation and characterization of an IgG2 antibody containing a cyclic imide in CDR1 of light chain by hydrophobic interaction chromatography and mass spectrometry.

  Hydrophobic interaction chromatography (HIC) was used to separate populations of recombinant IgG2 antibody that were created as a result of prolonged …

  Authors: John Valliere-Douglass, Laura Jones, Diana Shpektor, Paul Kodama, Alison Wallace, Alain Balland, Robert Bailey, Yuling Zhang

  Source: Analytical chemistry. 2008 May 1

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• Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex.

  Noggin and sclerostin are bone morphogenetic protein (BMP) antagonists that modulate mitogenic activity through sequestering BMPs. Little is known of …

  Authors: David G Winkler, Changpu Yu, James C Geoghegan, Ethan W Ojala, John E Skonier, Diana Shpektor, May K Sutherland, John A Latham

  Source: The Journal of biological chemistry. 2004 Aug 27

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• Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins.

  High bone mass diseases are caused both by activating mutations in the Wnt pathway and by loss of SOST, a bone morphogenetic protein (BMP) antagonist,…

  Authors: David G Winkler, May S Kung Sutherland, Ethan Ojala, Eileen Turcott, James C Geoghegan, Diana Shpektor, John E Skonier, Changpu Yu, John A Latham

  Source: The Journal of biological chemistry. 2005 Jan 28

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• Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.

  There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory process…

  Authors: David G Winkler, May Kung Sutherland, James C Geoghegan, Changpu Yu, Trenton Hayes, John E Skonier, Diana Shpektor, Mechtild Jonas, Brian R Kovacevich, Karen Staehling-Hampton,…

  Source: The EMBO journal. 2003 Dec 1

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