1 to 10 of 14 literature results

• Designing heart performance by gene transfer.

  The birth of molecular cardiology can be traced to the development and implementation of high-fidelity genetic approaches for manipulating the heart. …

  Authors: Jennifer Davis, Margaret V Westfall, Dewayne Townsend, Michael Blankinship, Todd J Herron, Guadalupe Guerrero-Serna, Wang Wang, Eric Devaney, Joseph M Metzger

  Source: Physiological reviews. 2008 Oct

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• Dystrophic heart failure blocked by membrane sealant poloxamer.

  Dystrophin deficiency causes Duchenne muscular dystrophy (DMD) in humans, an inherited and progressive disease of striated muscle deterioration that f…

  Authors: Soichiro Yasuda, DeWayne Townsend, Daniel E Michele, Elizabeth G Favre, Sharlene M Day, Joseph M Metzger

  Source: Nature. 2005 Aug 18

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• Cardiac consequences to skeletal muscle-centric therapeutics for Duchenne muscular dystrophy.

  Duchenne muscular dystrophy (DMD) is a fatal disease of muscle deterioration. Duchenne muscular dystrophy affects all striated muscles in the body, in…

  Authors: DeWayne Townsend, Soichiro Yasuda, Jeffrey Chamberlain, Joseph M Metzger

  Source: Trends in cardiovascular medicine. 2009 Feb

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• Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum.

  Enteric neural activity modulates active transepithelial ion transport in the intestine. We investigated the neural circuits mediating neurogenic secr…

  Authors: DeWayne Townsend, Melissa A Casey, David R Brown

  Source: European journal of pharmacology. 2005 Sep 20

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• Characterization of specific delta-opioid binding sites in the distal small intestine of swine.

  Delta-opioid receptors modulate neurogenic smooth muscle contractions and mucosal ion transport in the porcine distal small intestine. We compared spe…

  Authors: DeWayne Townsend, David R Brown

  Source: European journal of pharmacology. 2003 Dec 15

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• Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs.

  Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration caused by lack of the cytoskeletal protein dystrophin. Dystrophi…

  Authors: Dewayne Townsend, Immanuel Turner, Soichiro Yasuda, Joshua Martindale, Jennifer Davis, Michael Shillingford, Joe N Kornegay, Joseph M Metzger

  Source: The Journal of clinical investigation. 2010 Mar 15

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• Cardiomyopathy of Duchenne muscular dystrophy: pathogenesis and prospect of membrane sealants as a new therapeutic approach.

  Duchenne muscular dystrophy (DMD) is a devastating progressive disease of striated muscle deterioration. This fatal X-linked disorder results from the…

  Authors: DeWayne Townsend, Soichiro Yasuda, Joseph Metzger

  Source: Expert review of cardiovascular therapy. 2007 Jan

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• Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle.

  Duchenne muscular dystrophy (DMD) is a fatal disease characterized by deterioration of striated muscle, affecting skeletal and cardiac muscles. Recent…

  Authors: DeWayne Townsend, Soichiro Yasuda, Sheng Li, Jeffrey S Chamberlain, Joseph M Metzger

  Source: Molecular therapy : the journal of the American Society of Gene Therapy. 2008 May

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• Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure.

  Duchenne muscular dystrophy (DMD) is a fatal disease of striated muscle deterioration resulting from the loss of the cytoskeletal protein dystrophin. …

  Authors: DeWayne Townsend, Michael J Blankinship, James M Allen, Paul Gregorevic, Jeffrey S Chamberlain, Joseph M Metzger

  Source: Molecular therapy : the journal of the American Society of Gene Therapy. 2007 Jun

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• Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure.

  Oxygen metabolism is a strong predictor of the general health and fitness of an organism. In this study, we hypothesized that a divergence in intrinsi…

  Authors: Nathan J Palpant, Michael L Szatkowski, Wang Wang, DeWayne Townsend, Fikru B Bedada, Lauren G Koch, Steven L Britton, Joseph M Metzger

  Source: PloS one. 2009

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