1 to 9 of 9 literature results

• Microduplications of 16p11.2 are associated with schizophrenia.

  Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental …

  Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…

  Source: Nature genetics. 2009 Nov

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• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

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• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia.

  BACKGROUND: There is support that Neuregulin 1 (NRG1) plays a role in susceptibility to schizophrenia but limited evidence for its involvement in bipo…

  Authors: Lyudmila Georgieva, Albena Dimitrova, Dobril Ivanov, Ivan Nikolov, Nigel M Williams, Detelina Grozeva, Irina Zaharieva, Draga Toncheva, Michael J Owen, George Kirov,…

  Source: Biological psychiatry. 2008 Sep 1

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• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

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• Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder.

  CONTEXT: Family and twin data suggest that, in addition to susceptibility genes specific for bipolar disorder or schizophrenia, genes exist that contr…

  Authors: Elaine K Green, Rachel Raybould, Stuart Macgregor, Katherine Gordon-Smith, Jess Heron, Sally Hyde, Detelina Grozeva, Marian Hamshere, Nigel Williams, Michael J Owen,…

  Source: Archives of general psychiatry. 2005 Jun

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• Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

  We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosin…

  Authors: Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Paul R Burton, David G Clayton, Lon R Cardon, Nick Craddock, Panos Deloukas, Audrey Duncanson, Dominic P Kwiatkowski, Mark I McCarthy,…

  Source: Nature genetics. 2007 Nov

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• Affective temperaments across the bipolar-unipolar spectrum: Examination of the TEMPS-A in 927 patients and controls.

  OBJECTIVE: There is currently a great deal of interest in the use of affective temperaments as possible intermediate phenotypes for bipolar disorder. …

  Authors: Arianna Di Florio, Marian Hamshere, Liz Forty, Elaine K Green, Detelina Grozeva, Ian Jones, Sian Caesar, Christine Fraser, Katherine Gordon-Smith, Lisa Jones,…

  Source: Journal of affective disorders. 2009 Oct 31

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• P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

  The chromosomal region 12q24 has been previously implicated by linkage studies of both bipolar disorder and unipolar mood disorder and we have reporte…

  Authors: Elaine K Green, Detelina Grozeva, Rachel Raybould, Gareth Elvidge, Stuart Macgregor, Ian Craig, Anne Farmer, Peter McGuffin, Liz Forty, Lisa Jones,…

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009 Jan 21

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