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Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system (CNS) characterized by a wide range of clinical signs. The …
Authors: Ingunn M Stromnes, Lauren M Cerretti, Denny Liggitt, Robert A Harris, Joan M Goverman
Source: Nature medicine. 2008 Mar
View Free Full TextTransforming growth factor-beta (TGF-beta) has been implicated in the control of differentiation and proliferation of multiple cell types. However, a …
Authors: Julien C Marie, Denny Liggitt, Alexander Y Rudensky
Source: Immunity. 2006 Sep
View Full TextThe immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is req…
Authors: Hannah M Kerns, Byoung Y Ryu, Brigid V Stirling, Blythe D Sather, Alexander Astrakhan, Stephanie Humblet-Baron, Denny Liggitt, David J Rawlings
Source: Blood. 2010 Mar 18
View Full TextIt is widely accepted that T helper type 1 (T(H)1) cytokines such as interferon-gamma (IFN-gamma) antagonize allergic diseases mediated by T(H)2 cytok…
Authors: Martin E Dahl, Karim Dabbagh, Denny Liggitt, Sung Kim, David B Lewis
Source: Nature immunology. 2004 Mar
View Full TextThe cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increa…
Authors: Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell, Steven F Ziegler
Source: Nature immunology. 2005 Oct
View Full TextNearly 15 years have elapsed since the US Food and Drug Administration last approved a major new hematopoietic cytokine. Promiscuous binding to multip…
Authors: Michael A Weinreich, Ingrid Lintmaer, Linlin Wang, H Denny Liggitt, Michael A Harkey, C Anthony Blau
Source: Blood. 2006 Dec 1
View Free Full TextNaturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a cr…
Authors: Chyi-Song Hsieh, Yuqiong Liang, Aaron J Tyznik, Steven G Self, Denny Liggitt, Alexander Y Rudensky
Source: Immunity. 2004 Aug
View Full TextExpression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor pa…
Authors: Jeannette Philipp-Staheli, Kyung-Hoon Kim, Shannon R Payne, Kay E Gurley, Denny Liggitt, Gary Longton, Christopher J Kemp
Source: Cancer cell. 2002 May
View Full TextPneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate…
Authors: Christy L Ventura, Roger Higdon, Laura Hohmann, Daniel Martin, Eugene Kolker, H Denny Liggitt, Shawn J Skerrett, Craig E Rubens
Source: Infection and immunity. 2008 Dec
View Free Full TextThe corepressor mSin3A is the core component of a chromatin-modifying complex that is recruited by multiple gene-specific transcriptional repressors. …
Authors: Shaun M Cowley, Brian M Iritani, Susan M Mendrysa, Tina Xu, Pei Feng Cheng, Jason Yada, H Denny Liggitt, Robert N Eisenman
Source: Molecular and cellular biology. 2005 Aug
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