1 to 10 of 49 literature results

• Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

  Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system (CNS) characterized by a wide range of clinical signs. The …

  Authors: Ingunn M Stromnes, Lauren M Cerretti, Denny Liggitt, Robert A Harris, Joan M Goverman

  Source: Nature medicine. 2008 Mar

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• Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.

  Transforming growth factor-beta (TGF-beta) has been implicated in the control of differentiation and proliferation of multiple cell types. However, a …

  Authors: Julien C Marie, Denny Liggitt, Alexander Y Rudensky

  Source: Immunity. 2006 Sep

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• B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

  The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is req…

  Authors: Hannah M Kerns, Byoung Y Ryu, Brigid V Stirling, Blythe D Sather, Alexander Astrakhan, Stephanie Humblet-Baron, Denny Liggitt, David J Rawlings

  Source: Blood. 2010 Mar 18

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• Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells.

  It is widely accepted that T helper type 1 (T(H)1) cytokines such as interferon-gamma (IFN-gamma) antagonize allergic diseases mediated by T(H)2 cytok…

  Authors: Martin E Dahl, Karim Dabbagh, Denny Liggitt, Sung Kim, David B Lewis

  Source: Nature immunology. 2004 Mar

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• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.

  The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increa…

  Authors: Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell, Steven F Ziegler

  Source: Nature immunology. 2005 Oct

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• Growth factor receptors as regulators of hematopoiesis.

  Nearly 15 years have elapsed since the US Food and Drug Administration last approved a major new hematopoietic cytokine. Promiscuous binding to multip…

  Authors: Michael A Weinreich, Ingrid Lintmaer, Linlin Wang, H Denny Liggitt, Michael A Harkey, C Anthony Blau

  Source: Blood. 2006 Dec 1

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• Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

  Naturally arising CD25+ CD4+ regulatory T cells (TR) play an important role in the prevention of autoimmunity. TCR specificity is thought to play a cr…

  Authors: Chyi-Song Hsieh, Yuqiong Liang, Aaron J Tyznik, Steven G Self, Denny Liggitt, Alexander Y Rudensky

  Source: Immunity. 2004 Aug

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• Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.

  Expression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor pa…

  Authors: Jeannette Philipp-Staheli, Kyung-Hoon Kim, Shannon R Payne, Kay E Gurley, Denny Liggitt, Gary Longton, Christopher J Kemp

  Source: Cancer cell. 2002 May

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• Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.

  Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate…

  Authors: Christy L Ventura, Roger Higdon, Laura Hohmann, Daniel Martin, Eugene Kolker, H Denny Liggitt, Shawn J Skerrett, Craig E Rubens

  Source: Infection and immunity. 2008 Dec

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• The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

  The corepressor mSin3A is the core component of a chromatin-modifying complex that is recruited by multiple gene-specific transcriptional repressors. …

  Authors: Shaun M Cowley, Brian M Iritani, Susan M Mendrysa, Tina Xu, Pei Feng Cheng, Jason Yada, H Denny Liggitt, Robert N Eisenman

  Source: Molecular and cellular biology. 2005 Aug

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