1 to 10 of 24 literature results

• Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

  Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determi…

  Authors: Sharon Y Gidekel Friedlander, Gerald C Chu, Eric L Snyder, Nomeda Girnius, Gregory Dibelius, Denise Crowley, Eliza Vasile, Ronald A DePinho, Tyler Jacks

  Source: Cancer cell. 2009 Nov 6

  View Full Text

• Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.

  Epithelial ovarian tumors present a complex clinical, diagnostic and therapeutic challenge because of the difficulty of early detection, lack of known…

  Authors: Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley, Tyler Jacks

  Source: Nature medicine. 2005 Jan

  View Full Text

• Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.

  miR-17 approximately 92, miR-106b approximately 25, and miR-106a approximately 363 belong to a family of highly conserved miRNA clusters. Amplificatio…

  Authors: Andrea Ventura, Amanda G Young, Monte M Winslow, Laura Lintault, Alex Meissner, Stefan J Erkeland, Jamie Newman, Roderick T Bronson, Denise Crowley, James R Stone,…

  Source: Cell. 2008 Mar 7

  View Free Full Text

• Identification of bronchioalveolar stem cells in normal lung and lung cancer.

  Injury models have suggested that the lung contains anatomically and functionally distinct epithelial stem cell populations. We have isolated such a r…

  Authors: Carla F Bender Kim, Erica L Jackson, Amber E Woolfenden, Sharon Lawrence, Imran Babar, Sinae Vogel, Denise Crowley, Roderick T Bronson, Tyler Jacks

  Source: Cell. 2005 Jun 17

  View Full Text

• A spatially and temporally restricted mouse model of soft tissue sarcoma.

  Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we h…

  Authors: David G Kirsch, Daniela M Dinulescu, John B Miller, Jan Grimm, Philip M Santiago, Nathan P Young, G Petur Nielsen, Bradley J Quade, Christopher J Chaber, Christian P Schultz,…

  Source: Nature medicine. 2007 Aug

  View Full Text

• Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.

  Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also occur in the germline…

  Authors: Alice T Shaw, Alexander Meissner, James A Dowdle, Denise Crowley, Margaret Magendantz, Chensi Ouyang, Tiziana Parisi, Jayaraj Rajagopal, Leah J Blank, Roderick T Bronson,…

  Source: Genes & development. 2007 Mar 15

  View Free Full Text

• Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.

  The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 …

  Authors: Kenneth P Olive, David A Tuveson, Zachary C Ruhe, Bob Yin, Nicholas A Willis, Roderick T Bronson, Denise Crowley, Tyler Jacks

  Source: Cell. 2004 Dec 17

  View Full Text

• Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.

  p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the …

  Authors: Elsa R Flores, Shomit Sengupta, John B Miller, Jamie J Newman, Roderick Bronson, Denise Crowley, Annie Yang, Frank McKeon, Tyler Jacks

  Source: Cancer cell. 2005 Apr

  View Full Text

• p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.

  The tumour-suppressor gene p53 is frequently mutated in human cancers and is important in the cellular response to DNA damage. Although the p53 family…

  Authors: Elsa R Flores, Kenneth Y Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon, Tyler Jacks

  Source: Nature. 2002 Apr 4

  View Full Text

• Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin.

  Alternatively spliced variants of fibronectin (FN) containing exons EIIIA and EIIIB are expressed around newly forming vessels in development and dise…

  Authors: Sophie Astrof, Denise Crowley, Richard O Hynes

  Source: Developmental biology. 2007 Nov 1

  View Free Full Text