1 to 4 of 4 literature results

• GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

  T cell anergy may serve to limit autoreactive T cell responses. We examined early changes in gene expression after antigen-TCR signaling in the presen…

  Authors: Niroshana Anandasabapathy, Gregory S Ford, Debra Bloom, Claire Holness, Violette Paragas, Christine Seroogy, Heidi Skrenta, Marie Hollenhorst, C Garrison Fathman, Luis Soares

  Source: Immunity. 2003 Apr

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• Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

  Antigen-specific immunotolerance limits the expansion of self-reactive T cells involved in autoimmune diseases. Here, we show that the E3 ubiquitin li…

  Authors: Myung-Shin Jeon, Alex Atfield, K Venuprasad, Connie Krawczyk, Renu Sarao, Chris Elly, Chun Yang, Sudha Arya, Kurt Bachmaier, Leon Su,…

  Source: Immunity. 2004 Aug

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• Alemtuzumab induction and recurrence of glomerular disease after kidney transplantation.

  BACKGROUND: An increase in the incidence of autoimmune diseases has been described in patients receiving alemtuzumab. METHODS: To determine whether in…

  Authors: Julio Pascual, Joshua D Mezrich, Arjang Djamali, Glen Leverson, L Thomas Chin, José Torrealba, Debra Bloom, Barbara Voss, Bryan N Becker, Stuart J Knechtle,…

  Source: Transplantation. 2007 Jun 15

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• The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.

  Acquisition of the anergy phenotype in T cells is blocked by inhibitors of protein synthesis and calcineurin activity, suggesting that anergic T cells…

  Authors: Christine M Seroogy, Luis Soares, Erik A Ranheim, Leon Su, Claire Holness, Debra Bloom, C Garrison Fathman

  Source: Journal of immunology (Baltimore, Md. : 1950). 2004 Jul 1

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