1 to 10 of 65 literature results

• Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain.

  Cholesterol 24-hydroxylase is a highly conserved cytochrome P450 that is responsible for the majority of cholesterol turnover in the vertebrate centra…

  Authors: David W Russell, Rebekkah W Halford, Denise M O Ramirez, Rahul Shah, Tiina Kotti

  Source: Annual review of biochemistry. 2009

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• The enzymes, regulation, and genetics of bile acid synthesis.

  The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals. Synthesis provides a direct means of conver…

  Authors: David W Russell

  Source: Annual review of biochemistry. 2003

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• Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors.

  Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy. However, the use of gam…

  Authors: Thomas R Bauer, James M Allen, Mehreen Hai, Laura M Tuschong, Iram F Khan, Erik M Olson, Rima L Adler, Tanya H Burkholder, Yu-Chen Gu, David W Russell,…

  Source: Nature medicine. 2008 Jan

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• Adeno-associated virus vectors integrate at chromosome breakage sites.

  Adeno-associated virus (AAV) vectors transduce cells by multiple pathways, including integration at nonhomologous chromosomal locations by an unknown …

  Authors: Daniel G Miller, Lisa M Petek, David W Russell

  Source: Nature genetics. 2004 Jul

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• Transplanted bone marrow regenerates liver by cell fusion.

  Results from several experimental systems suggest that cells from one tissue type can form other tissue types after transplantation. This could be due…

  Authors: George Vassilopoulos, Pei-Rong Wang, David W Russell

  Source: Nature. 2003 Apr 24

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• Fifty years of advances in bile acid synthesis and metabolism.

  There are two major pathways that mammalian cells use to supply themselves with cholesterol, one involving the synthesis of sterols from acetyl-CoA an…

  Authors: David W Russell

  Source: Journal of lipid research. 2009 Apr

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• Chromosomal effects of adeno-associated virus vector integration.

  Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Tr…

  Authors: Daniel G Miller, Elizabeth A Rutledge, David W Russell

  Source: Nature genetics. 2002 Feb

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• Gene targeting in vivo by adeno-associated virus vectors.

  Therapeutic gene delivery typically involves the addition of a transgene expression cassette to mutant cells. This approach is complicated by transgen…

  Authors: Daniel G Miller, Pei-Rong Wang, Lisa M Petek, Roli K Hirata, Mark S Sands, David W Russell

  Source: Nature biotechnology. 2006 Aug

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• Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

  A major obstacle limiting gene therapy for diseases of the heart and skeletal muscles is an inability to deliver genes systemically to muscles of an a…

  Authors: Paul Gregorevic, Michael J Blankinship, James M Allen, Robert W Crawford, Leonard Meuse, Daniel G Miller, David W Russell, Jeffrey S Chamberlain

  Source: Nature medicine. 2004 Aug

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• Clinical importance of the cytochromes P450.

  The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign che…

  Authors: Daniel W Nebert, David W Russell

  Source: Lancet. 2002 Oct 12

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