1 to 10 of 36 literature results

• Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer.

  Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By estab…

  Authors: Chunru Lin, Liuqing Yang, Bogdan Tanasa, Kasey Hutt, Bong-gun Ju, Kenny Ohgi, Jie Zhang, David W Rose, Xiang-Dong Fu, Christopher K Glass,…

  Source: Cell. 2009 Dec 11

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• Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules.

  While the transcriptional machinery has been extensively dissected at the molecular level, little is known about regulation of chromosomal organizatio…

  Authors: Esperanza Nunez, Young-Soo Kwon, Kasey R Hutt, Qidong Hu, Maria Dafne Cardamone, Kenneth A Ohgi, Ivan Garcia-Bassets, David W Rose, Christopher K Glass, Michael G Rosenfeld,…

  Source: Cell. 2008 Mar 21

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• Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors.

  Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actu…

  Authors: Ivan Garcia-Bassets, Young-Soo Kwon, Francesca Telese, Gratien G Prefontaine, Kasey R Hutt, Christine S Cheng, Bong-Gun Ju, Kenneth A Ohgi, Jianxun Wang, Laure Escoubet-Lozach,…

  Source: Cell. 2007 Feb 9

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• TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.

  A key strategy to achieve regulated gene expression in higher eukaryotes is to prevent illegitimate signal-independent activation by imposing robust c…

  Authors: Valentina Perissi, Claudio Scafoglio, Jie Zhang, Kenneth A Ohgi, David W Rose, Christopher K Glass, Michael G Rosenfeld

  Source: Molecular cell. 2008 Mar 28

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• A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.

  Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has essential roles in adipogenesis and glucose homeostasis, and is a molecular target o…

  Authors: Gabriel Pascual, Amy L Fong, Sumito Ogawa, Amir Gamliel, Andrew C Li, Valentina Perissi, David W Rose, Timothy M Willson, Michael G Rosenfeld, Christopher K Glass

  Source: Nature. 2005 Sep 29

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• A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.

  The mechanisms that control the precisely regulated switch from gene repression to gene activation represent a central question in mammalian developme…

  Authors: Valentina Perissi, Aneel Aggarwal, Christopher K Glass, David W Rose, Michael G Rosenfeld

  Source: Cell. 2004 Feb 20

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• Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.

  Defining the precise molecular strategies that coordinate patterns of transcriptional responses to specific signals is central for understanding norma…

  Authors: Ping Zhu, Sung Hee Baek, Eliot M Bourk, Kenneth A Ohgi, Ivan Garcia-Bassets, Hideki Sanjo, Shizuo Akira, Paul F Kotol, Christopher K Glass, Michael G Rosenfeld,…

  Source: Cell. 2006 Feb 10

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• Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.

  Defining the molecular strategies that integrate diverse signalling pathways in the expression of specific gene programmes that are critical in homeos…

  Authors: Jung Hwa Kim, Bogyou Kim, Ling Cai, Hee June Choi, Kenneth A Ohgi, Chris Tran, Charlie Chen, Chin Ha Chung, Otmar Huber, David W Rose,…

  Source: Nature. 2005 Apr 14

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• Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.

  Switching specific patterns of gene repression and activation in response to precise temporal/spatial signals is critical for normal development. Here…

  Authors: Bong-Gun Ju, Derek Solum, Eun Joo Song, Kong-Joo Lee, David W Rose, Christopher K Glass, Michael G Rosenfeld

  Source: Cell. 2004 Dec 17

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• Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

  Defining the molecular mechanisms that integrate diverse signaling pathways at the level of gene transcription remains a central issue in biology. Her…

  Authors: Sung Hee Baek, Kenneth A Ohgi, David W Rose, Edward H Koo, Christopher K Glass, Michael G Rosenfeld

  Source: Cell. 2002 Jul 12

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