1 to 10 of 62 literature results

• Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions.

  Tissue development, differentiation, and physiology require specialized cellular adhesion and signal transduction at sites of cell-cell contact. Scaff…

  Authors: Lars Funke, Srikanth Dakoji, David S Bredt

  Source: Annual review of biochemistry. 2005

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• AMPA receptor subunit-specific regulation by a distinct family of type II TARPs.

  AMPA-type glutamate receptors (GluRs) play major roles in excitatory synaptic transmission. Neuronal AMPA receptors comprise GluR subunits and transme…

  Authors: Akihiko S Kato, Edward R Siuda, Eric S Nisenbaum, David S Bredt

  Source: Neuron. 2008 Sep 25

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• Stargazin modulates AMPA receptor gating and trafficking by distinct domains.

  AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors mediate fast excitatory synaptic transmission in the brain. These ion chann…

  Authors: Susumu Tomita, Hillel Adesnik, Masayuki Sekiguchi, Wei Zhang, Keiji Wada, James R Howe, Roger A Nicoll, David S Bredt

  Source: Nature. 2005 Jun 23

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• TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.

  A family of transmembrane AMPA receptor regulatory proteins (TARPs) profoundly affects the trafficking and gating of AMPA receptors (AMPARs). Although…

  Authors: Aaron D Milstein, Wei Zhou, Siavash Karimzadegan, David S Bredt, Roger A Nicoll

  Source: Neuron. 2007 Sep 20

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• Early events in glutamate receptor trafficking.

  Glutamate receptors are the primary mediators of excitatory synaptic transmission in the mammalian central nervous system. Activity-dependent changes …

  Authors: Wim Vandenberghe, David S Bredt

  Source: Current opinion in cell biology. 2004 Apr

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• Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex.

  Neurotransmission requires proper organization of synaptic vesicle pools and rapid release of vesicle contents upon presynaptic depolarization. Geneti…

  Authors: Olav Olsen, Kimberly A Moore, Roger A Nicoll, David S Bredt

  Source: Current opinion in cell biology. 2006 Apr

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• Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

  Trafficking of AMPA receptors (AMPA-Rs) to and from synapses controls the strength of excitatory synaptic transmission. However, proteins that cluster…

  Authors: Guillermo M Elias, Lars Funke, Valentin Stein, Seth G Grant, David S Bredt, Roger A Nicoll

  Source: Neuron. 2006 Oct 19

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• AMPA receptor trafficking at excitatory synapses.

  Excitatory synapses in the CNS release glutamate, which acts primarily on two sides of ionotropic receptors: AMPA receptors and NMDA receptors. AMPA r…

  Authors: David S Bredt, Roger A Nicoll

  Source: Neuron. 2003 Oct 9

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• Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs.

  Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however,…

  Authors: Susumu Tomita, Valentin Stein, Tim J Stocker, Roger A Nicoll, David S Bredt

  Source: Neuron. 2005 Jan 20

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• TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity.

  Synaptic plasticity involves activity-dependent trafficking of AMPA-type glutamate receptors. Numerous cytoplasmic scaffolding proteins are postulated…

  Authors: Nathalie Rouach, Keith Byrd, Ronald S Petralia, Guillermo M Elias, Hillel Adesnik, Susumu Tomita, Siavash Karimzadegan, Colin Kealey, David S Bredt, Roger A Nicoll

  Source: Nature neuroscience. 2005 Nov

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