1 to 10 of 59 literature results

• Accelerated genetic drift on chromosome X during the human dispersal out of Africa.

  Comparisons of chromosome X and the autosomes can illuminate differences in the histories of males and females as well as shed light on the forces of …

  Authors: Alon Keinan, James C Mullikin, Nick Patterson, David Reich

  Source: Nature genetics. 2009 Jan

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• Reconstructing Indian population history.

  India has been underrepresented in genome-wide surveys of human variation. We analyse 25 diverse groups in India to provide strong evidence for two an…

  Authors: David Reich, Kumarasamy Thangaraj, Nick Patterson, Alkes L Price, Lalji Singh

  Source: Nature. 2009 Sep 24

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• Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans.

  Large data sets on human genetic variation have been collected recently, but their usefulness for learning about history and natural selection has bee…

  Authors: Alon Keinan, James C Mullikin, Nick Patterson, David Reich

  Source: Nature genetics. 2007 Oct

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• Population differentiation as a test for selective sweeps.

  Selective sweeps can increase genetic differentiation among populations and cause allele frequency spectra to depart from the expectation under neutra…

  Authors: Hua Chen, Nick Patterson, David Reich

  Source: Genome research. 2010 Mar

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• Genetic evidence for complex speciation of humans and chimpanzees.

  The genetic divergence time between two species varies substantially across the genome, conveying important information about the timing and process o…

  Authors: Nick Patterson, Daniel J Richter, Sante Gnerre, Eric S Lander, David Reich

  Source: Nature. 2006 Jun 29

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• Principal components analysis corrects for stratification in genome-wide association studies.

  Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associati…

  Authors: Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich

  Source: Nature genetics. 2006 Aug

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• A common genetic risk factor for colorectal and prostate cancer.

  Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,8…

  Authors: Christopher A Haiman, Loïc Le Marchand, Jennifer Yamamato, Daniel O Stram, Xin Sheng, Laurence N Kolonel, Anna H Wu, David Reich, Brian E Henderson

  Source: Nature genetics. 2007 Aug

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• The difficulty of avoiding false positives in genome scans for natural selection.

  Several studies have found evidence for more positive selection on the chimpanzee lineage compared with the human lineage since the two species split.…

  Authors: Swapan Mallick, Sante Gnerre, Paul Muller, David Reich

  Source: Genome research. 2009 May

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• A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.

  Heart failure is a leading cause of mortality in South Asians. However, its genetic etiology remains largely unknown. Cardiomyopathies due to sarcomer…

  Authors: Perundurai S Dhandapany, Sakthivel Sadayappan, Yali Xue, Gareth T Powell, Deepa Selvi Rani, Prathiba Nallari, Taranjit Singh Rai, Madhu Khullar, Pedro Soares, Ajay Bahl,…

  Source: Nature genetics. 2009 Feb

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• MYH9 is associated with nondiabetic end-stage renal disease in African Americans.

  As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that suscepti…

  Authors: W H Linda Kao, Michael J Klag, Lucy A Meoni, David Reich, Yvette Berthier-Schaad, Man Li, Josef Coresh, Nick Patterson, Arti Tandon, Neil R Powe,…

  Source: Nature genetics. 2008 Oct

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