1 to 10 of 42 literature results

• Smurf1 zaps the talin head.

  Focal adhesion turnover is essential for cell migration. New results show that the talin head liberated from talin by calpain II cleavage has a key ro…

  Authors: David R Critchley

  Source: Nature cell biology. 2009 May

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• Rapid leukocyte migration by integrin-independent flowing and squeezing.

  All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extr…

  Authors: Tim Lämmermann, Bernhard L Bader, Susan J Monkley, Tim Worbs, Roland Wedlich-Söldner, Karin Hirsch, Markus Keller, Reinhold Förster, David R Critchley, Reinhard Fässler,…

  Source: Nature. 2008 May 1

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• The structure and regulation of vinculin.

  Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for both cell-cell and cell-extracellular matrix (focal adhesio…

  Authors: Wolfgang H Ziegler, Robert C Liddington, David R Critchley

  Source: Trends in cell biology. 2006 Sep

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• Talin depletion reveals independence of initial cell spreading from integrin activation and traction.

  Cell spreading, adhesion and remodelling of the extracellular matrix (ECM) involve bi-directional signalling and physical linkages between the ECM, in…

  Authors: Xian Zhang, Guoying Jiang, Yunfei Cai, Susan J Monkley, David R Critchley, Michael P Sheetz

  Source: Nature cell biology. 2008 Sep

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• Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.

  Mechanical forces on matrix-integrin-cytoskeleton linkages are crucial for cell viability, morphology and organ function. The production of force depe…

  Authors: Guoying Jiang, Grégory Giannone, David R Critchley, Emiko Fukumoto, Michael P Sheetz

  Source: Nature. 2003 Jul 17

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• Structural basis for vinculin activation at sites of cell adhesion.

  Vinculin is a highly conserved intracellular protein with a crucial role in the maintenance and regulation of cell adhesion and migration. In the cyto…

  Authors: Constantina Bakolitsa, Daniel M Cohen, Laurie A Bankston, Andrey A Bobkov, Gregory W Cadwell, Lisa Jennings, David R Critchley, Susan W Craig, Robert C Liddington

  Source: Nature. 2004 Jul 29

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• Calpain-mediated proteolysis of talin regulates adhesion dynamics.

  Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent…

  Authors: Santos J Franco, Mary A Rodgers, Benjamin J Perrin, Jaewon Han, David A Bennin, David R Critchley, Anna Huttenlocher

  Source: Nature cell biology. 2004 Oct

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• An essential role for talin during alpha(M)beta(2)-mediated phagocytosis.

  The cytoskeletal, actin-binding protein talin has been previously implicated in phagocytosis in Dictyostelium discoideum and mammalian phagocytes. How…

  Authors: Jenson Lim, Agnès Wiedemann, George Tzircotis, Susan J Monkley, David R Critchley, Emmanuelle Caron

  Source: Molecular biology of the cell. 2007 Mar

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• Interaction of paxillin with poly(A)-binding protein 1 and its role in focal adhesion turnover and cell migration.

  We have previously identified poly(A)-binding protein 1 (PABP1) as a ligand for paxillin and shown that the paxillin-PABP1 complex undergoes nucleocyt…

  Authors: Alison J Woods, Theodoros Kantidakis, Hisataka Sabe, David R Critchley, Jim C Norman

  Source: Molecular and cellular biology. 2005 May

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• Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1.

  Cytoskeletal proteins of the tensin family couple integrins to the actin cytoskeleton. They are found in both focal adhesions and the fibrillar adhesi…

  Authors: Katherine Clark, Jonathan D Howe, Christine E Pullar, J Angelo Green, Vira V Artym, Kenneth M Yamada, David R Critchley

  Source: Journal of cellular biochemistry. 2010 Mar 1

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