1 to 10 of 39 literature results

• Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.

  Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune respo…

  Authors: Lorraine A O' Reilly, Lin Tai, Lily Lee, Elizabeth A Kruse, Stephanie Grabow, W Douglas Fairlie, Nicole M Haynes, David M Tarlinton, Jian-Guo Zhang, Gabrielle T Belz,…

  Source: Nature. 2009 Oct 1

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• Give and take in the germinal center.

  Authors: Stephen L Nutt, David M Tarlinton

  Source: Nature immunology. 2010 Jun

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• CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers.

  To segregate the many contributions that B cell receptor (BCR)-mediated signals make to immune responses, we have analyzed here B cells deficient in t…

  Authors: Nicholas D Huntington, Yuekang Xu, Hamsa Puthalakath, Amanda Light, Simon N Willis, Andreas Strasser, David M Tarlinton

  Source: Nature immunology. 2006 Feb

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• FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis.

  The survival of long-lived plasma cells, which produce most serum immunoglobulin, is central to humoral immunity. We found here that the inhibitory Fc…

  Authors: Zou Xiang, Antony J Cutler, Rebecca J Brownlie, Kirsten Fairfax, Kate E Lawlor, Eva Severinson, Elizabeth U Walker, Rudolf A Manz, David M Tarlinton, Kenneth G C Smith

  Source: Nature immunology. 2007 Apr

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• Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation.

  Naive B lymphocytes undergo isotype switching and develop into immunoglobulin-secreting cells to generate the appropriate class and amount of antibody…

  Authors: Jhagvaral Hasbold, Lynn M Corcoran, David M Tarlinton, Stuart G Tangye, Philip D Hodgkin

  Source: Nature immunology. 2004 Jan

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• Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.

  Interleukin 15 (IL-15) promotes the survival of natural killer (NK) cells by preventing apoptosis through mechanisms unknown at present. Here we ident…

  Authors: Nicholas D Huntington, Hamsa Puthalakath, Priscilla Gunn, Edwina Naik, Ewa M Michalak, Mark J Smyth, Hyacinth Tabarias, Mariapia A Degli-Esposti, Grant Dewson, Simon N Willis,…

  Source: Nature immunology. 2007 Aug

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• Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow.

  Long-lived plasma cells in the bone marrow produce memory antibodies that provide immune protection persisting for decades after infection or vaccinat…

  Authors: Oliver Winter, Katrin Moser, Elodie Mohr, Dimitra Zotos, Henriette Kaminski, Martin Szyska, Katrin Roth, David M Wong, Christof Dame, David M Tarlinton,…

  Source: Blood. 2010 Jun 10

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• Memory B cells: effectors of long-lived immune responses.

  Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent en…

  Authors: Stuart G Tangye, David M Tarlinton

  Source: European journal of immunology. 2009 Aug

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• Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

  Blimp-1 is considered an essential regulator of the terminal differentiation of B cells into antibody-secreting plasma cells. We show here that Rag1-/…

  Authors: Axel Kallies, Jhagvaral Hasbold, Kirsten Fairfax, Clare Pridans, Dianne Emslie, Brent S McKenzie, Andrew M Lew, Lynn M Corcoran, Philip D Hodgkin, David M Tarlinton,…

  Source: Immunity. 2007 May

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• Lyn tyrosine kinase: accentuating the positive and the negative.

  Lyn, one of several Src-family tyrosine kinases in immune cells, is noted for its ability to negatively regulate signaling pathways through phosphoryl…

  Authors: Yuekang Xu, Kenneth W Harder, Nicholas D Huntington, Margaret L Hibbs, David M Tarlinton

  Source: Immunity. 2005 Jan

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