1 to 10 of 52 literature results

• Acute alcohol action and desensitization of ligand-gated ion channels.

  Ethanol exerts its biological actions through multiple receptors, including ion channels. Ion channels that are sensitive to pharmacologically relevan…

  Authors: Alex M Dopico, David M Lovinger

  Source: Pharmacological reviews. 2009 Mar

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• Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill.

  The learning of new skills is characterized by an initial phase of rapid improvement in performance and a phase of more gradual improvements as skills…

  Authors: Henry H Yin, Shweta Prasad Mulcare, Monica R F Hilário, Emily Clouse, Terrell Holloway, Margaret I Davis, Anita C Hansson, David M Lovinger, Rui M Costa

  Source: Nature neuroscience. 2009 Mar

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• Laboratory models of alcoholism: treatment target identification and insight into mechanisms.

  Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for c…

  Authors: David M Lovinger, John C Crabbe

  Source: Nature neuroscience. 2005 Nov

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• Developmental alteration of endocannabinoid retrograde signaling in the hippocampus.

  Endocannabinoids are lipid derivatives that mediate paracrine and juxtacrine signaling between cells. In the hippocampal CA1 region, a retrograde endo…

  Authors: Ping Jun Zhu, David M Lovinger

  Source: Journal of neurophysiology. 2010 Feb

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• Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.

  Long-term depression (LTD) of the synapse formed between cortical pyramidal neurons and striatal medium spiny neurons is central to many theories of m…

  Authors: Zhongfeng Wang, Li Kai, Michelle Day, Jennifer Ronesi, Henry H Yin, Jun Ding, Tatiana Tkatch, David M Lovinger, D James Surmeier

  Source: Neuron. 2006 May 4

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• The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole.

  Allosteric modulation of ligand-gated ion channels can play important roles in shaping synaptic transmission. The function of the 5-hydroxytryptamine …

  Authors: Xiang-Qun Hu, David M Lovinger

  Source: Neuropharmacology. 2008 Jun

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• Electrophysiological properties and gap junction coupling of striatal astrocytes.

  The striatum is the biggest nucleus of the basal ganglia and receives input from almost all cortical regions, substantia nigra and the thalamus. Stria…

  Authors: Louise Adermark, David M Lovinger

  Source: Neurochemistry international. 2008 Jun

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• Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.

  Neurotensin is a peptide that has been suggested to mimic the actions of antipsychotics, but little is known about how it affects synaptic transmissio…

  Authors: Henry H Yin, Louise Adermark, David M Lovinger

  Source: Neuropharmacology. 2008 Jan

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• Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity.

  Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depressi…

  Authors: Ping Jun Zhu, David M Lovinger

  Source: Journal of neurophysiology. 2007 Jun

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• Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region.

  Endocannabinoids released from the postsynaptic neuronal membrane can activate presynaptic CB1 receptors and inhibit neurotransmitter release. In hipp…

  Authors: Anton Sheinin, Giuseppe Talani, Margaret I Davis, David M Lovinger

  Source: Journal of neurophysiology. 2008 Aug

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