1 to 10 of 78 literature results

• LXRS and FXR: the yin and yang of cholesterol and fat metabolism.

  Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respe…

  Authors: Nada Y Kalaany, David J Mangelsdorf

  Source: Annual review of physiology. 2006

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• 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.

  The cardioprotective effects of estrogen are mediated by receptors expressed in vascular cells. Here we show that 27-hydroxycholesterol (27HC), an abu…

  Authors: Michihisa Umetani, Hideharu Domoto, Andrew K Gormley, Ivan S Yuhanna, Carolyn L Cummins, Norman B Javitt, Kenneth S Korach, Philip W Shaul, David J Mangelsdorf

  Source: Nature medicine. 2007 Oct

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• Prevention of cholesterol gallstone disease by FXR agonists in a mouse model.

  Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and …

  Authors: Antonio Moschetta, Angie L Bookout, David J Mangelsdorf

  Source: Nature medicine. 2004 Dec

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• Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.

  Expression of the Drosophila orphan nuclear receptor DHR78 is regulated by the steroid hormone ecdysone and is required for growth and viability durin…

  Authors: Keith D Baker, Robert B Beckstead, David J Mangelsdorf, Carl S Thummel

  Source: Genes & development. 2007 Feb 15

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• International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

  The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X…

  Authors: David D Moore, Shigeaki Kato, Wen Xie, David J Mangelsdorf, Daniel R Schmidt, Rui Xiao, Steven A Kliewer

  Source: Pharmacological reviews. 2006 Dec

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• Nuclear receptor expression links the circadian clock to metabolism.

  As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to ci…

  Authors: Xiaoyong Yang, Michael Downes, Ruth T Yu, Angie L Bookout, Weimin He, Marty Straume, David J Mangelsdorf, Ronald M Evans

  Source: Cell. 2006 Aug 25

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• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.

  In multicellular organisms, the ability to regulate reproduction, development, and nutrient utilization coincided with the evolution of nuclear recept…

  Authors: Angie L Bookout, Yangsik Jeong, Michael Downes, Ruth T Yu, Ronald M Evans, David J Mangelsdorf

  Source: Cell. 2006 Aug 25

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• International Union of Pharmacology. LX. Retinoic acid receptors.

  Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone r…

  Authors: Pierre Germain, Pierre Chambon, Gregor Eichele, Ronald M Evans, Mitchell A Lazar, Mark Leid, Angel R De Lera, Reuben Lotan, David J Mangelsdorf, Hinrich Gronemeyer

  Source: Pharmacological reviews. 2006 Dec

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• International Union of Pharmacology. LXIII. Retinoid X receptors.

  The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and…

  Authors: Pierre Germain, Pierre Chambon, Gregor Eichele, Ronald M Evans, Mitchell A Lazar, Mark Leid, Angel R De Lera, Reuben Lotan, David J Mangelsdorf, Hinrich Gronemeyer

  Source: Pharmacological reviews. 2006 Dec

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• Identification of a hormonal basis for gallbladder filling.

  The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-1…

  Authors: Mihwa Choi, Antonio Moschetta, Angie L Bookout, Li Peng, Michihisa Umetani, Sam R Holmstrom, Kelly Suino-Powell, H Eric Xu, James A Richardson, Robert D Gerard,…

  Source: Nature medicine. 2006 Nov

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