1 to 10 of 55 literature results

• Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.

  Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a ro…

  Authors: Matthew P Strout, David G Schatz

  Source: Cancer cell. 2009 Sep 8

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• Balancing AID and DNA repair during somatic hypermutation.

  Somatic hypermutation (SHM) of Ig genes in B cells is crucial for antibody affinity maturation. The reaction is initiated by cytosine deamination of I…

  Authors: Man Liu, David G Schatz

  Source: Trends in immunology. 2009 Apr

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• Two levels of protection for the B cell genome during somatic hypermutation.

  Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initi…

  Authors: Man Liu, Jamie L Duke, Daniel J Richter, Carola G Vinuesa, Christopher C Goodnow, Steven H Kleinstein, David G Schatz

  Source: Nature. 2008 Feb 14

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• RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

  Coordinated recombination of homologous antigen receptor loci is thought to be important for allelic exclusion. Here we show that homologous immunoglo…

  Authors: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael,…

  Source: Nature immunology. 2009 Jun

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• Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

  Chromosomal translocations involving immunoglobulin heavy chain (Igh) switch regions and an oncogene such as Myc represent initiating events in the de…

  Authors: Shyam Unniraman, Shaoming Zhou, David G Schatz

  Source: Nature immunology. 2004 Nov

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• DNA deaminases converge on adaptive immunity.

  Authors: David G Schatz

  Source: Nature immunology. 2007 Jun

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• Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity.

  Somatic hypermutation is critical for the generation of high-affinity antibodies and effective immune responses, but its molecular mechanism remains p…

  Authors: F Nina Papavasiliou, David G Schatz

  Source: Cell. 2002 Apr

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• Targeting of AID-mediated sequence diversification by cis-acting determinants.

  After their assembly by V(D)J recombination, immunoglobulin (Ig) genes undergo somatic hypermutation, gene conversion, and class switch recombination …

  Authors: Shu Yuan Yang, David G Schatz

  Source: Advances in immunology. 2007

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• Histone modifications associated with somatic hypermutation.

  A number of modified histones, including acetylated H3 and H4 and phosphorylated H2AX (gammaH2AX), are associated with V(D)J recombination and class s…

  Authors: Valerie H Odegard, Sean T Kim, Shannon M Anderson, Mark J Shlomchik, David G Schatz

  Source: Immunity. 2005 Jul

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• B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.

  Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H)) occurs only in B cells, suggesting it is inhibited in other lineages. Here we found that in t…

  Authors: Kristen Johnson, David L Pflugh, Duonan Yu, David G T Hesslein, Kuo-I Lin, Alfred L M Bothwell, Andrei Thomas-Tikhonenko, David G Schatz, Kathryn Calame

  Source: Nature immunology. 2004 Aug

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