1 to 10 of 65 literature results

• International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

  The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X…

  Authors: David D Moore, Shigeaki Kato, Wen Xie, David J Mangelsdorf, Daniel R Schmidt, Rui Xiao, Steven A Kliewer

  Source: Pharmacological reviews. 2006 Dec

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• Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor.

  6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437/AHPN) and 4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC…

  Authors: Lulu Farhana, Marcia I Dawson, Mark Leid, Li Wang, David D Moore, Gang Liu, Zeben Xia, Joseph A Fontana

  Source: Cancer research. 2007 Jan 1

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• Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.

  Farnesoid X receptor (FXR, NR1H4) is a member of the nuclear hormone receptor superfamily, which plays an essential role in regulating bile acid, lipi…

  Authors: Fan Yang, Xiongfei Huang, Tangsheng Yi, Yun Yen, David D Moore, Wendong Huang

  Source: Cancer research. 2007 Feb 1

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• No, really, how do they work?'.

  Authors: David D Moore

  Source: Genes & development. 2005 Feb 15

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• GUGULIPID: a natural cholesterol-lowering agent.

  The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both an…

  Authors: Nancy L Urizar, David D Moore

  Source: Annual review of nutrition. 2003

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• Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.

  Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by xenobiotic inducers of cytochromes P450 is part of a pleiotropic…

  Authors: Adrian Roth, Renate Looser, Michel Kaufmann, Sharon M Blättler, Franck Rencurel, Wendong Huang, David D Moore, Urs A Meyer

  Source: Molecular pharmacology. 2008 Apr

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• Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor.

  BACKGROUND & AIMS: In the rat, an increase in ileal bile acid binding protein (IBABP) expression occurs during the third postnatal week. In vitro stud…

  Authors: Sandy T Hwang, Nancy L Urizar, David D Moore, Susan J Henning

  Source: Gastroenterology. 2002 May

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• Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.

  The induction of hepatic drug metabolizing enzymes alters not only the metabolism of the xenobiotic substances that induce them but also the metabolis…

  Authors: Mohammed Qatanani, Jun Zhang, David D Moore

  Source: Endocrinology. 2005 Mar

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• Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.

  The nuclear hormone receptor constitutive androstane receptor (CAR, NR1I3) regulates detoxification of xenobiotics and endogenous molecules, and has b…

  Authors: David Masson, Mohamed Qatanani, Anne Laure Sberna, Rui Xiao, Jean Paul Pais de Barros, Jacques Grober, Valerie Deckert, Anne Athias, Philippe Gambert, Laurent Lagrost,…

  Source: Journal of lipid research. 2008 Aug

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• Redundant pathways for negative feedback regulation of bile acid production.

  The orphan nuclear hormone receptor SHP has been proposed to have a key role in the negative feedback regulation of bile acid production. Consistent w…

  Authors: Li Wang, Yoon-Kwang Lee, Donnie Bundman, Yunqing Han, Sundararajah Thevananther, Chang Soo Kim, Steven S Chua, Ping Wei, Richard A Heyman, Michael Karin,…

  Source: Developmental cell. 2002 Jun

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