1 to 8 of 8 literature results

• Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.

  Cell-based screening using phenotypic assays is a useful means of identifying bioactive chemicals for use as tools to elucidate complex cellular proce…

  Authors: David C Schriemer, Danielle Kemmer, Michel Roberge

  Source: Combinatorial chemistry & high throughput screening. 2008 Sep

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• Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

  BACKGROUND: Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provid…

  Authors: Danielle Kemmer, Lianne M McHardy, Shawn Hoon, Delphine Rebérioux, Guri Giaever, Corey Nislow, Calvin D Roskelley, Michel Roberge

  Source: BMC microbiology. 2009

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• Yeast as a tool to uncover the cellular targets of drugs.

  Knowledge of the spectrum of cellular proteins targeted by experimental therapeutic agents would greatly facilitate drug development. However, identif…

  Authors: Christopher M Sturgeon, Danielle Kemmer, Hilary J Anderson, Michel Roberge

  Source: Biotechnology journal. 2006 Mar

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• Gene characterization index: assessing the depth of gene annotation.

  BACKGROUND: We introduce the Gene Characterization Index, a bioinformatics method for scoring the extent to which a protein-encoding gene is functiona…

  Authors: Danielle Kemmer, Raf M Podowski, Dimas Yusuf, Jochen Brumm, Warren Cheung, Claes Wahlestedt, Boris Lenhard, Wyeth W Wasserman

  Source: PloS one. 2008

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• Exploring the Foundation of Genomics: A Northern Blot Reference set for the Comparative Analysis of Transcript Profiling Technologies.

  In this paper we aim to create a reference data collection of Northern blot results and demonstrate how such a collection can enable a quantitative co…

  Authors: Danielle Kemmer, Margareta Faxén, Emily Hodges, Jonathan Lim, Elena Herzog, Elsebrit Ljungström, Anders Lundmark, Mary K Olsen, Raf Podowski, Erik L L Sonnhammer,…

  Source: Comparative and functional genomics. 2004

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• NovelFam3000--uncharacterized human protein domains conserved across model organisms.

  BACKGROUND: Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cell…

  Authors: Danielle Kemmer, Raf M Podowski, David Arenillas, Jonathan Lim, Emily Hodges, Peggy Roth, Erik L L Sonnhammer, Christer Höög, Wyeth W Wasserman

  Source: BMC genomics. 2006

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• Ulysses - an application for the projection of molecular interactions across species.

  We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interact…

  Authors: Danielle Kemmer, Yong Huang, Sohrab P Shah, Jonathan Lim, Jochen Brumm, Macaire M S Yuen, John Ling, Tao Xu, Wyeth W Wasserman, B F Francis Ouellette

  Source: Genome biology. 2005

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• Whose genome is next?

  Authors: Danielle Kemmer, Andrew Fraser

  Source: Genome biology. 2002

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