1 to 9 of 9 literature results

• Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.

  Epithelial ovarian tumors present a complex clinical, diagnostic and therapeutic challenge because of the difficulty of early detection, lack of known…

  Authors: Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley, Tyler Jacks

  Source: Nature medicine. 2005 Jan

  View Full Text

• A spatially and temporally restricted mouse model of soft tissue sarcoma.

  Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we h…

  Authors: David G Kirsch, Daniela M Dinulescu, John B Miller, Jan Grimm, Philip M Santiago, Nathan P Young, G Petur Nielsen, Bradley J Quade, Christopher J Chaber, Christian P Schultz,…

  Source: Nature medicine. 2007 Aug

  View Full Text

• Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.

  Cyclooxygenases-1 and -2 (Cox-1 and Cox-2) are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. The role of C…

  Authors: Takiko Daikoku, Susanne Tranguch, Irina N Trofimova, Daniela M Dinulescu, Tyler Jacks, Alexander Yu Nikitin, Denise C Connolly, Sudhansu K Dey

  Source: Cancer research. 2006 Mar 1

  View Full Text

• Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer.

  Epithelial ovarian cancer is the deadliest female reproductive tract malignancy in Western countries. Less than 25% of cases are diagnosed when the ca…

  Authors: Karen L Abbott, Alison V Nairn, Erica M Hall, Marc B Horton, John F McDonald, Kelley W Moremen, Daniela M Dinulescu, Michael Pierce

  Source: Proteomics. 2008 Aug

  View Full Text

• c-CBL is not required for leukemia induction by Bcr-Abl in mice.

  Bcr-Abl tyrosine kinase activity is essential for the pathogenesis of chronic myeloid leukemia (CML). A number of Bcr-Abl substrates have been identif…

  Authors: Daniela M Dinulescu, Lisa J Wood, Lei Shen, Marc Loriaux, Christopher L Corless, Alec W Gross, Ruibao Ren, Michael W N Deininger, Brian J Druker

  Source: Oncogene. 2003 Dec 4

  View Full Text

• Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.

  Although epidemiologic evidence for the ability of combined oral contraception (OC) to reduce the risk of ovarian cancer (OvCa) is convincing, the bio…

  Authors: Iris L Romero, Ilyssa O Gordon, Sujatha Jagadeeswaran, Keeley L Mui, Woo Seok Lee, Daniela M Dinulescu, Thomas N Krausz, Helen H Kim, Melissa L Gilliam, Ernst Lengyel

  Source: Cancer prevention research (Philadelphia, Pa.). 2009 Sep

  View Full Text

• Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.

  The microRNA let-7 regulates late embryonic development by suppressing expression of a number of genes such as c-myc and RAS as well as the embryonic …

  Authors: Sun-Mi Park, Scott Shell, Amir Reza Radjabi, Robert Schickel, Christine Feig, Ben Boyerinas, Daniela M Dinulescu, Ernst Lengyel, Marcus E Peter

  Source: Cell cycle (Georgetown, Tex.). 2007 Nov 1

  View Full Text

• Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer.

  Mullerian Inhibiting Substance (MIS), a biological modifier that causes regression of Mullerian ducts in male embryos, is effective as a single agent …

  Authors: Rafael Pieretti-Vanmarcke, Patricia K Donahoe, Lisa A Pearsall, Daniela M Dinulescu, Denise C Connolly, Elkan F Halpern, Michael V Seiden, David T MacLaughlin

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Nov 14

  View Free Full Text

• Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness.

  The recent identification of "side population" (SP) cells in a number of unrelated human cancers and their normal tissue sources has renewed interest …

  Authors: Paul P Szotek, Rafael Pieretti-Vanmarcke, Peter T Masiakos, Daniela M Dinulescu, Denise Connolly, Rosemary Foster, David Dombkowski, Frederic Preffer, David T Maclaughlin, Patricia K Donahoe

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 25

  View Free Full Text