1 to 10 of 31 literature results

• Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.

  Communication between endothelial cells (ECs) and mural cells is critical in vascular maturation. Genetic studies suggest that angiopoietin/Tie2 signa…

  Authors: Hanako Kobayashi, Laura M DeBusk, Yael O Babichev, Daniel J Dumont, Pengnian Charles Lin

  Source: Blood. 2006 Aug 15

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• Angiopoietin-2 impairs revascularization after limb ischemia.

  Angiopoietins play important roles in the formation of neovessels and complex vascular networks. Angiopoietin (Ang)-1 and Ang-2 belong to a family of …

  Authors: Yvonne Reiss, Jasmin Droste, Matthias Heil, Silvia Tribulova, Mirko H H Schmidt, Wolfgang Schaper, Daniel J Dumont, Karl H Plate

  Source: Circulation research. 2007 Jul 6

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• Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization.

  The receptor tyrosine kinase Tie2 is highly expressed in endothelial cells and is crucial for angiogenesis and vascular maintenance. The ligands for T…

  Authors: Elena Bogdanovic, Vicky P K H Nguyen, Daniel J Dumont

  Source: Journal of cell science. 2006 Sep 1

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• Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth.

  Vascular endothelial growth factor (VEGF) is a potent proangiogenic protein that activates VEGF receptor (VEGFR) tyrosine kinases expressed by vascula…

  Authors: John M L Ebos, Christina R Lee, Elena Bogdanovic, Jennifer Alami, Paul Van Slyke, Giulio Francia, Ping Xu, Anthony J Mutsaers, Daniel J Dumont, Robert S Kerbel

  Source: Cancer research. 2008 Jan 15

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• Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis.

  Development of antiangiogenic therapies would be significantly facilitated by quantitative surrogate pharmacodynamic markers. Circulating peripheral b…

  Authors: Yuval Shaked, Francesco Bertolini, Shan Man, Michael S Rogers, Dave Cervi, Thomas Foutz, Kimberley Rawn, Daniel Voskas, Daniel J Dumont, Yaacov Ben-David,…

  Source: Cancer cell. 2005 Jan

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• Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1.

  The tyrosine kinase receptor Tie2 is expressed on endothelial cells, and together with its ligand angiopoietin-1 (Ang1), is important for angiogenesis…

  Authors: Elena Bogdanovic, Neil Coombs, Daniel J Dumont

  Source: Histochemistry and cell biology. 2009 Aug

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• Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.

  The development of the cardiovascular system and the development of the early hematopoietic systems are closely related, and both require signaling th…

  Authors: Kazunobu Tachibana, Nina Jones, Daniel J Dumont, Mira C Puri, Alan Bernstein

  Source: Molecular and cellular biology. 2005 Jun

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• Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival.

  Tie2 is a receptor-type tyrosine kinase expressed on hematopoietic stem cells and endothelial cells. We used cultured embryonic stem (ES) cells to det…

  Authors: Isao Hamaguchi, Tohru Morisada, Masaki Azuma, Kyoko Murakami, Madoka Kuramitsu, Takuo Mizukami, Kazuyuki Ohbo, Kazunari Yamaguchi, Yuichi Oike, Daniel J Dumont,…

  Source: Blood. 2006 Feb 1

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• Cell-based angiopoietin-1 gene therapy for acute lung injury.

  RATIONALE: The acute respiratory distress syndrome is a significant cause of morbidity and mortality in critically ill patients. Angiopoietin-1 (Ang-1…

  Authors: Sarah D McCarter, Shirley H J Mei, Patrick F H Lai, Qiu Wang Zhang, Colleen H Parker, Renée S Suen, Roberta D Hood, Yidan D Zhao, Yupu Deng, Robin N N Han,…

  Source: American journal of respiratory and critical care medicine. 2007 May 15

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• Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.

  Dok-R has previously been shown to associate with the epidermal growth factor receptor (EGFR) and become tyrosine phosphorylated in response to EGF st…

  Authors: Paul Van Slyke, Mariano Loza Coll, Zubin Master, Harold Kim, Jorge Filmus, Daniel J Dumont

  Source: Molecular and cellular biology. 2005 May

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