1 to 10 of 25 literature results

• From mRNA to tumor suppressor.

  The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility…

  Authors: Dan Mercola, John Welsh

  Source: Nature genetics. 2004 Sep

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• Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress.

  The NH2-terminal Jun kinases (JNKs) function in diverse roles through phosphorylation and activation of AP-1 components including ATF2 and c-Jun. Howe…

  Authors: Jun Hayakawa, Shalu Mittal, Yipeng Wang, Kemal S Korkmaz, Eileen Adamson, Christopher English, Masahide Ohmichi, Masahide Omichi, Michael McClelland, Dan Mercola

  Source: Molecular cell. 2004 Nov 19

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• Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.

  The early growth response 1 (Egr1) gene is a transcription factor that acts as both a tumor suppressor and a tumor promoter. Egr1-null mouse embryo fi…

  Authors: Anja Krones-Herzig, Shalu Mittal, Kelly Yule, Hongyan Liang, Chris English, Rafael Urcis, Tarun Soni, Eileen D Adamson, Dan Mercola

  Source: Cancer research. 2005 Jun 15

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• Expression profile of human gingival fibroblasts induced by interleukin-1beta reveals central role of nuclear factor-kappa B in stabilizing human gingival fibroblasts during inflammation.

  BACKGROUND: Interleukin (IL)-1beta is a key cytokine in the pathogenesis of periodontitis, and it induces inflammatory mediators in periodontal diseas…

  Authors: Saynur Vardar-Sengul, Shilpi Arora, Haluk Baylas, Dan Mercola

  Source: Journal of periodontology. 2009 May

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• WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells.

  Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and with invasive bladder…

  Authors: Yaxiong Tang, Anne R Simoneau, Wu-xiang Liao, Guo Yi, Christopher Hope, Feng Liu, Shunqiang Li, Jun Xie, Randall F Holcombe, Frances A Jurnak,…

  Source: Molecular cancer therapeutics. 2009 Feb

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• Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo.

  Transcription factor early growth response-1 (Egr-1) is a crucial regulator of cell growth, differentiation and survival. Several observations suggest…

  Authors: Véronique Baron, Giorgia De Gregorio, Anja Krones-Herzig, Thierry Virolle, Antonella Calogero, Rafael Urcis, Dan Mercola

  Source: Oncogene. 2003 Jul 3

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• Timing of consent for the research use of surgically removed tissue: is postoperative consenting acceptable?

  Authors: Robert Hewitt, Peter H Watson, Rajiv Dhir, Roger Aamodt, Gerry Thomas, Dan Mercola, William E Grizzle, Manuel M Morente

  Source: Cancer. 2009 Jan 1

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• Antisense to the early growth response-1 gene (Egr-1) inhibits prostate tumor development in TRAMP mice.

  Egr-1 is a transcription factor induced by stress or injury, mitogens, and differentiation factors. Egr-1 regulates the expression of genes involved i…

  Authors: Véronique Baron, Stephan Duss, Johng Rhim, Dan Mercola

  Source: Annals of the New York Academy of Sciences. 2003 Dec

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• Egr1 signaling in prostate cancer.

  Egr1 is a multifunctional transcription factor regulating a remarkable spectrum of cellular responses from survival to apoptosis, growth to growth arr…

  Authors: Eileen Adamson, Ian de Belle, Shalu Mittal, Yipeng Wang, Jun Hayakawa, Kemal Korkmaz, David O'Hagan, Michael McClelland, Dan Mercola

  Source: Cancer biology & therapy. 2003 Nov-Dec

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• The wisdom of the commons: ensemble tree classifiers for prostate cancer prognosis.

  MOTIVATION: Classification and regression trees have long been used for cancer diagnosis and prognosis. Nevertheless, instability and variable selecti…

  Authors: James A Koziol, Anne C Feng, Zhenyu Jia, Yipeng Wang, Seven Goodison, Michael McClelland, Dan Mercola

  Source: Bioinformatics (Oxford, England). 2009 Jan 1

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