1 to 10 of 15 literature results

• Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells.

  A major goal of immunotherapy for autoimmune diseases and transplantation is induction of regulatory T cells that mediate immunologic tolerance. The m…

  Authors: Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre S Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller,…

  Source: Nature medicine. 2006 Jun

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• Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody.

  Anti-CD3 monoclonal antibody (mAb) has been shown to induce tolerance and to be an effective treatment for diabetes both in animal models and in human…

  Authors: Hiroki Ishikawa, Hirofumi Ochi, Mei-Ling Chen, Dan Frenkel, Ruth Maron, Howard L Weiner

  Source: Diabetes. 2007 Aug

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• A nasal proteosome adjuvant activates microglia and prevents amyloid deposition.

  OBJECTIVE: We assessed whether peripheral activation of microglia by a nasal proteosome-based adjuvant (Protollin) that has been given safely to human…

  Authors: Dan Frenkel, Lindsay Puckett, Sanja Petrovic, Weiming Xia, Guiquan Chen, Jose Vega, Adi Dembinsky-Vaknin, Jie Shen, Martin Plante, David S Burt,…

  Source: Annals of neurology. 2008 May

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• Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury.

  Myocardial ischemia with subsequent reperfusion (MI/R) can lead to significant myocardial damage. Ischemia initiates inflammation at the blood-microva…

  Authors: Dan Frenkel, Alok S Pachori, Lunan Zhang, Adi Dembinsky-Vaknin, Dorit Farfara, Sanja Petrovic-Stojkovic, Victor J Dzau, Howard L Weiner

  Source: International immunology. 2009 Jul

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• Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

  SJL mice are highly susceptible to proteolipid protein (PLP) 139-151-induced experimental allergic encephalomyelitis (EAE). The disease is characteriz…

  Authors: Xingmin Zhang, Jayagopala Reddy, Hirofumi Ochi, Dan Frenkel, Vijay K Kuchroo, Howard L Weiner

  Source: International immunology. 2006 Apr

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• Generation of anti-beta-amyloid antibodies via phage display technology.

  The EFRH sequence, found to be the main anti-aggregating epitope corresponding to amino acids 3-6 of beta-amyloid peptide (AbetaP), was displayed on a…

  Authors: Dan Frenkel, Mally Dori, Beka Solomon

  Source: Vaccine. 2004 Jun 23

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• New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity.

  One of the major goals for the immunotherapy of autoimmune diseases is the induction of regulatory T cells that mediate immunologic tolerance. Parente…

  Authors: Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller,…

  Source: Journal of the neurological sciences. 2008 Nov 15

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• Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke.

  Mucosal tolerance has been used successfully to treat animal models of autoimmune diseases and is being tested in human diseases. In this work we demo…

  Authors: Dan Frenkel, Zhihong Huang, Ruth Maron, Djordje N Koldzic, Michael A Moskowitz, Howard L Weiner

  Source: Journal of the neurological sciences. 2005 Jun 15

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• Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization.

  Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and…

  Authors: Dan Frenkel, Ilse Dewachter, Fred Van Leuven, Beka Solomon

  Source: Vaccine. 2003 Mar 7

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• Immunology and immunotherapy of Alzheimer's disease.

  Although Alzheimer's disease is considered to be a degenerative brain disease, it is clear that the immune system has an important role in the disease…

  Authors: Howard L Weiner, Dan Frenkel

  Source: Nature reviews. Immunology. 2006 May

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