1 to 10 of 17 literature results

• Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.

  AIMS: The inhibitory effect of angiotensin II type 1 receptor blockers (ARBs) on P-glycoprotein (P-gp) was examined to evaluate their clinical drug-dr…

  Authors: Emi Kamiyama, Daisuke Nakai, Tsuyoshi Mikkaichi, Noriko Okudaira, Osamu Okazaki

  Source: Life sciences. 2010 Jan 2

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• Structure-based targeting of bioactive proteins into cypovirus polyhedra and application to immobilized cytokines for mammalian cell culture.

  Certain insect viruses produce stable infectious micro-crystals called polyhedra which function to protect the virus after the death of infected larva…

  Authors: Hiroshi Ijiri, Fasséli Coulibaly, Gento Nishimura, Daisuke Nakai, Elaine Chiu, Chiemi Takenaka, Keiko Ikeda, Hiroshi Nakazawa, Norio Hamada, Eiji Kotani,…

  Source: Biomaterials. 2009 Sep

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• Enhancement of the inhibitory activity of oatp antisense oligonucleotides by incorporation of 2'-O,4'-C-ethylene-bridged nucleic acids (ENA) without a loss of subtype selectivity.

  Antisense oligonucleotides (AONs) that specifically target the genes of rat organic anion transporting polypeptide (oatp) subtypes were selected by us…

  Authors: Miho Takagi, Koji Morita, Daisuke Nakai, Rie Nakagomi, Taro Tokui, Makoto Koizumi

  Source: Biochemistry. 2004 Apr 20

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• Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys.

  1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbonyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, …

  Authors: Ken Kitayama, Daisuke Nakai, Keita Kono, Arthur Gerritsen van der Hoop, Hitoshi Kurata, Elly C de Wit, Louis H Cohen, Toshimori Inaba, Takafumi Kohama

  Source: European journal of pharmacology. 2006 Jun 6

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• Microdisplacement sensor using an optically trapped microprobe based on the interference scale.

  Positioning technology is one of the most important technologies for developing microsystems. In particular, displacement sensors are necessary for po…

  Authors: Masaki Michihata, Terutake Hayashi, Daisuke Nakai, Yasuhiro Takaya

  Source: The Review of scientific instruments. 2010 Jan

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• T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.

  Liver X receptors (LXR alpha and LXR beta) are nuclear receptors, which are important regulators of cholesterol and lipid metabolism. LXRs control gen…

  Authors: Naoki Terasaka, Ayano Hiroshima, Tadashi Koieyama, Naoko Ubukata, Yuka Morikawa, Daisuke Nakai, Toshimori Inaba

  Source: FEBS letters. 2003 Feb 11

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• Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method.

  Ultracentrifugation methods have been widely used for the determination of the free fraction of compounds in plasma, especially for lipophilic compoun…

  Authors: Daisuke Nakai, Kazuyo Kumamoto, Chisa Sakikawa, Toshiyuki Kosaka, Taro Tokui

  Source: Journal of pharmaceutical sciences. 2004 Apr

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• Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.

  Many symptoms induced by isolation rearing of rodents may be relevant to neuropsychiatric disorders, including depression. However, identities of tran…

  Authors: Toshio Maekawa, Seungjoon Kim, Daisuke Nakai, Chieko Makino, Tsuyoshi Takagi, Hiroo Ogura, Kazuyuki Yamada, Bruno Chatton, Shunsuke Ishii

  Source: The EMBO journal. 2010 Jan 6

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• coq7/clk-1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q.

  coq7/clk-1 was isolated from a long-lived mutant of Caenorhabditis elegans, and shows sluggish behaviours and an extended lifespan. In C. elegans and …

  Authors: Daisuke Nakai, Takahiko Shimizu, Hidetoshi Nojiri, Satoshi Uchiyama, Hideo Koike, Mayumi Takahashi, Katsuiku Hirokawa, Takuji Shirasawa

  Source: Aging cell. 2004 Oct

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• Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells.

  The objective of this study was to determine an appropriate culture period to assess whether a compound of interest is transported by efflux transport…

  Authors: Emi Kamiyama, Daisuke Sugiyama, Daisuke Nakai, Shin-ichi Miura, Osamu Okazaki

  Source: Drug metabolism and disposition: the biological fate of chemicals. 2009 Sep

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