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The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.
The p75(NTR) acts as a tumor suppressor in the prostate, but its expression is lost as prostate cancer progresses and is minimal in established prosta…
Authors: Emily J Quann, Fatima Khwaja, Daniel Djakiew
Source: Cancer research. 2007 Dec 1
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The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.
Epidemiologic studies show that patients chronically consuming nonsteroidal anti-inflammatory drugs (NSAID) for arthritis exhibit a reduced incidence …
Authors: Emily J Quann, Fatima Khwaja, Kenton H Zavitz, Daniel Djakiew
Source: Cancer research. 2007 Apr 1
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Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to reduce inflammation and as analgesics by inhibition of cyclooxygenase-2. At higher concentra…
Authors: Fatima Khwaja, Jeff Allen, John Lynch, Peter Andrews, Daniel Djakiew
Source: Cancer research. 2004 Sep 1
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Carprofen induction of p75NTR-dependent apoptosis via the p38 mitogen-activated protein kinase pathway in prostate cancer cells.
The p75 neurotrophin receptor (p75(NTR)) functions as a tumor suppressor in prostate epithelial cells, where its expression declines with progression …
Authors: Fatima S Khwaja, Emily J Quann, Nagarajan Pattabiraman, Shehla Wynne, Daniel Djakiew
Source: Molecular cancer therapeutics. 2008 Nov
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The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells.
The p75 neurotrophin receptor (p75(NTR)) is a death receptor which belongs to the tumor necrosis factor receptor super-family of membrane proteins. Th…
Authors: Fatima Khwaja, Arshia Tabassum, Jeff Allen, Daniel Djakiew
Source: Biochemical and biophysical research communications. 2006 Mar 24
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The p75NTR mediates a bifurcated signal transduction cascade through the NF kappa B and JNK pathways to inhibit cell survival.
p75NTR is most abundantly expressed in the nervous system, but is also widely expressed in many other organs and tissues where it primarily functions …
Authors: Jeffrey Allen, Fatima Khwaja, Stephen Byers, Daniel Djakiew
Source: Experimental cell research. 2005 Mar 10
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The p75(NTR) metastasis suppressor inhibits urokinase plasminogen activator, matrix metalloproteinase-2 and matrix metalloproteinase-9 in PC-3 prostate cancer cells.
The p75 neurotrophin receptor (p75(NTR)) has been characterized as a metastasis and tumor suppressor in prostate cancer. In order to investigate the m…
Authors: Angèle Nalbandian, Daniel Djakiew
Source: Clinical & experimental metastasis. 2006
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Inhibition of cell-cycle effectors of proliferation in bladder tumor epithelial cells by the p75NTR tumor suppressor.
The neurotrophin (NTR) receptor (p75(NTR)) is a cell-surface glycoprotein that binds to the neurotrophin family of growth factors, of which the protot…
Authors: Fatima Khwaja, Daniel Djakiew
Source: Molecular carcinogenesis. 2003 Mar
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Molecular characterization of the loss of p75(NTR) expression in human prostate tumor cells.
The low-affinity nerve growth factor receptor p75(NTR) is a 75-kDa glycoprotein that belongs to the tumor necrosis factor receptor superfamily and has…
Source: Molecular carcinogenesis. 2001 May
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Human prostate cancer risk factors.
Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with similar likelihood of neoplastic foci found within the prosta…
Authors: David G Bostwick, Harry B Burke, Daniel Djakiew, Susan Euling, Shuk-mei Ho, Joseph Landolph, Howard Morrison, Babasaheb Sonawane, Tiffany Shifflett, David J Waters,…
Source: Cancer. 2004 Nov 15
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