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• NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

  Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In thi…

  Authors: Jason L Eriksen, Sarah A Sagi, Tawnya E Smith, Sascha Weggen, Pritam Das, D C McLendon, Victor V Ozols, Kevin W Jessing, Kenton H Zavitz, Edward H Koo,…

  Source: The Journal of clinical investigation. 2003 Aug

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• Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage.

  Presenilins (PSs) are polytopic membrane proteins that have been implicated as potential therapeutic targets in Alzheimer's disease because of their r…

  Authors: M P Murphy, S N Uljon, P E Fraser, A Fauq, H A Lookingbill, K A Findlay, T E Smith, P A Lewis, D C McLendon, R Wang,…

  Source: The Journal of biological chemistry. 2000 Aug 25

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