1 to 10 of 14 literature results

• The Fas-FADD death domain complex structure unravels signalling by receptor clustering.

  The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-associated death domain protein) and caspase 8 is a pivotal trigger of …

  Authors: Fiona L Scott, Boguslaw Stec, Cristina Pop, Małgorzata K Dobaczewska, JeongEun J Lee, Edward Monosov, Howard Robinson, Guy S Salvesen, Robert Schwarzenbacher, Stefan J Riedl

  Source: Nature. 2009 Feb 19

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• The nematode death machine in 3D.

  Regulated apoptosis is part of the development of the nematode Caenorhabditis elegans. In a recent paper in Nature, Yan et al. (2005) describe the in …

  Authors: Cristina Pop, Guy S Salvesen

  Source: Cell. 2005 Oct 21

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• The apoptosome activates caspase-9 by dimerization.

  The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The …

  Authors: Cristina Pop, John Timmer, Sabina Sperandio, Guy S Salvesen

  Source: Molecular cell. 2006 Apr 21

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• Role of proteolysis in caspase-8 activation and stabilization.

  Caspase-8 is an apoptotic protease that is activated at the cytosolic face of the cell membrane. Activation relies on adaptor-induced dimerization of …

  Authors: Cristina Pop, Patrick Fitzgerald, Douglas R Green, Guy S Salvesen

  Source: Biochemistry. 2007 Apr 10

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• Caspase assays: identifying caspase activity and substrates in vitro and in vivo.

  The measurement of general caspase activity and the quantification of purified recombinant caspases in vitro can be accomplished with relative ease. B…

  Authors: Cristina Pop, Guy S Salvesen, Fiona L Scott

  Source: Methods in enzymology. 2008

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• Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3.

  During maturation, procaspase-3 is cleaved at D175, which resides in a linker that connects the large and small subunits. The intersubunit linker also…

  Authors: Brett Feeney, Cristina Pop, Paul Swartz, Carla Mattos, A Clay Clark

  Source: Biochemistry. 2006 Nov 7

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• Mutations in the procaspase-3 dimer interface affect the activity of the zymogen.

  The interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center…

  Authors: Cristina Pop, Brett Feeney, Ashutosh Tripathy, A Clay Clark

  Source: Biochemistry. 2003 Oct 28

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• An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.

  We have examined the enzymatic activity of an uncleavable procaspase-3 mutant (D9A/D28A/D175A), which contains the wild-type catalytic residues in the…

  Authors: Kakoli Bose, Cristina Pop, Brett Feeney, A Clay Clark

  Source: Biochemistry. 2003 Oct 28

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• Human caspases: activation, specificity, and regulation.

  Caspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation. Activation of caspases occurs by a conserv…

  Authors: Cristina Pop, Guy S Salvesen

  Source: The Journal of biological chemistry. 2009 Aug 14

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• Improved free energy parameters for RNA pseudoknotted secondary structure prediction.

  Accurate prediction of RNA pseudoknotted secondary structures from the base sequence is a challenging computational problem. Since prediction algorith…

  Authors: Mirela S Andronescu, Cristina Pop, Anne E Condon

  Source: RNA (New York, N.Y.). 2010 Jan

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