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1 to 10 of 14 literature results
The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-associated death domain protein) and caspase 8 is a pivotal trigger of …
Authors: Fiona L Scott, Boguslaw Stec, Cristina Pop, MaĆgorzata K Dobaczewska, JeongEun J Lee, Edward Monosov, Howard Robinson, Guy S Salvesen, Robert Schwarzenbacher, Stefan J Riedl
Source: Nature. 2009 Feb 19
View Free Full TextRegulated apoptosis is part of the development of the nematode Caenorhabditis elegans. In a recent paper in Nature, Yan et al. (2005) describe the in …
Authors: Cristina Pop, Guy S Salvesen
Source: Cell. 2005 Oct 21
View Full TextThe apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The …
Authors: Cristina Pop, John Timmer, Sabina Sperandio, Guy S Salvesen
Source: Molecular cell. 2006 Apr 21
View Full TextCaspase-8 is an apoptotic protease that is activated at the cytosolic face of the cell membrane. Activation relies on adaptor-induced dimerization of …
Authors: Cristina Pop, Patrick Fitzgerald, Douglas R Green, Guy S Salvesen
Source: Biochemistry. 2007 Apr 10
View Full TextThe measurement of general caspase activity and the quantification of purified recombinant caspases in vitro can be accomplished with relative ease. B…
Authors: Cristina Pop, Guy S Salvesen, Fiona L Scott
Source: Methods in enzymology. 2008
View Full TextDuring maturation, procaspase-3 is cleaved at D175, which resides in a linker that connects the large and small subunits. The intersubunit linker also…
Authors: Brett Feeney, Cristina Pop, Paul Swartz, Carla Mattos, A Clay Clark
Source: Biochemistry. 2006 Nov 7
View Full TextThe interface of the procaspase-3 dimer plays a critical role in zymogen maturation. We show that replacement of valine 266, the residue at the center…
Authors: Cristina Pop, Brett Feeney, Ashutosh Tripathy, A Clay Clark
Source: Biochemistry. 2003 Oct 28
View Full TextWe have examined the enzymatic activity of an uncleavable procaspase-3 mutant (D9A/D28A/D175A), which contains the wild-type catalytic residues in the…
Authors: Kakoli Bose, Cristina Pop, Brett Feeney, A Clay Clark
Source: Biochemistry. 2003 Oct 28
View Full TextCaspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation. Activation of caspases occurs by a conserv…
Authors: Cristina Pop, Guy S Salvesen
Source: The Journal of biological chemistry. 2009 Aug 14
View Full TextAccurate prediction of RNA pseudoknotted secondary structures from the base sequence is a challenging computational problem. Since prediction algorith…
Authors: Mirela S Andronescu, Cristina Pop, Anne E Condon
Source: RNA (New York, N.Y.). 2010 Jan
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