1 to 6 of 6 literature results

• Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

  We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with…

  Authors: Philip L De Jager, Xiaoming Jia, Joanne Wang, Paul I W de Bakker, Linda Ottoboni, Neelum T Aggarwal, Laura Piccio, Soumya Raychaudhuri, Dong Tran, Cristin Aubin,…

  Source: Nature genetics. 2009 Jul

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• Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2.

  Acute necrotizing encephalopathy (ANE) is a rapidly progressive encephalopathy that can occur in otherwise healthy children after common viral infecti…

  Authors: Derek E Neilson, Mark D Adams, Caitlin M D Orr, Deborah K Schelling, Robert M Eiben, Douglas S Kerr, Jane Anderson, Alexander G Bassuk, Ann M Bye, Anne-Marie Childs,…

  Source: American journal of human genetics. 2009 Jan

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• Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

  Basal levels of C-reactive protein (CRP) have been associated with disease, particularly future cardiovascular events. Twin studies estimate 50% CRP h…

  Authors: Benjamin Rhodes, David L Morris, Lakshman Subrahmanyan, Cristin Aubin, Carlos F Mendes de Leon, Jeremiah F Kelly, Dennis A Evans, John C Whittaker, Jorge R Oksenberg, Philip L De Jager,…

  Source: Human genetics. 2008 Jul

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• Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.

  BACKGROUND: Prediction of susceptibility to multiple sclerosis (MS) might have important clinical applications, either as part of a diagnostic algorit…

  Authors: Philip L De Jager, Lori B Chibnik, Jing Cui, Joachim Reischl, Stephan Lehr, K Claire Simon, Cristin Aubin, David Bauer, Jürgen F Heubach, Rupert Sandbrink,…

  Source: Lancet neurology. 2009 Dec

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• IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

  Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by…

  Authors: Lisa M Maier, Christopher E Lowe, Jason Cooper, Kate Downes, David E Anderson, Christopher Severson, Pamela M Clark, Brian Healy, Neil Walker, Cristin Aubin,…

  Source: PLoS genetics. 2009 Jan

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• The role of the CD58 locus in multiple sclerosis.

  Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with demyelination and axonal loss. A whole genome associa…

  Authors: Philip L De Jager, Clare Baecher-Allan, Lisa M Maier, Ariel T Arthur, Linda Ottoboni, Lisa Barcellos, Jacob L McCauley, Stephen Sawcer, An Goris, Janna Saarela,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 31

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